Novel insights about the ascidian dopamine system: Pharmacology and phylogenetics of catecholaminergic receptors on the Phallusia nigra immune cells

Souza, Jessica Fernandes de; Mello, Andressa de Abreu; Portal, Taynan Motta; Fonseca, Rodrigo Nunes da; Barros, Cíntia Monteiro de

doi:10.1016/j.fsi.2020.11.022

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…As is the case for the sessile ascidian urochordate Ciona, the Oikopleura dioica genome contains no sequence with substantial resemblance to the bilaterian dopamine receptor genes. 26,28,29 We therefore performed a protein blast of the Ciona intestinalis gene proposed to encode an a2-ADR (GenBank: XP_002120235.3) 26 and obtained two Oikopleura protein sequence hits (GenBank: CBY09491.1 and GenBank: CBY37057.1) (Figure S3). These are two splice variants of the same gene (GSOIDG00008492001), differing in their N-terminal and C-terminal domains but sharing the same core sequence of the transmembrane domain and intracellular loop 3, which are usually responsible for G-protein coupling.…”

Section: Resultsmentioning

confidence: 99%

A Miniaturized Nigrostriatal-Like Circuit Regulating Locomotor Performance in a Protochordate

2023

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Section: Resultsmentioning

confidence: 99%

A Miniaturized Nigrostriatal-Like Circuit Regulating Locomotor Performance in a Protochordate

2023

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“…However, a recent study suggests that catecholaminergic receptors (e.g. adrenergic receptors) in ascidians may have special pharmacological characteristics which would allow them to bind D2-class receptors (93). In addition, it has been shown that a number of adrenergic receptors in vertebrates are capable of responding to dopamine (94)(95)(96)(97) This promiscuous interaction between the dopaminergic and adrenergic systems may be a novel way for these neuromodulators to exert their functions.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of behavioral dynamics in the protochordateCiona intestinalis

Athira

Dondorp

Rudolf

et al. 2021

Preprint

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Locomotion is broadly conserved in the animal kingdom, yet our understanding of how complex locomotor behaviors are generated and have evolved is relatively limited by the lack of an accurate description of their structural organization. Here we take a neuroethological approach to break down the motor behavioral repertoire of one of our nearest invertebrate relative, the protochordate Ciona intestinalis, into basic building blocks. Using machine vision, we track thousands of swimming larvae to obtain a feature-rich description of larval swimming and show that most of the postural variance can be captured by six basic shapes, which we term “Eigencionas”. Using multiple complementary approaches, we built representations of the larval behavioral dynamics and systematically reveal the global structure of behavior. By employing matrix profiling and subsequence time-series clustering, we reveal that Ciona swimming is rich in stereotyped behavioral motifs. Combining pharmacological inhibition of bioamine signaling with Hidden Markov Model we discover underlying behavioral states including multiple modes of roaming and dwelling. Finally, performing a spatio-temporal embedding of the postural features onto a behavioral space provides insight into the behavioral repertoire by project it to a low-dimensional space and highlights subtle light stimulus evoked behavioral differences.Taken together, Ciona larvae generate their spontaneous swimming and visuomotor behavioral repertoire by altering both their motor modules and transitions between, which are amenable to pharmacological perturbations, facilitating future functional and mechanistic investigations.

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“…In the adult, dopaminergic neurons have not been described. However, a molecular study by our group showed that dopaminergic receptors are present in the adult ascidian Phallusia nigra [ 78 ]. Currently, we are investigating potential effects of rotenone, using adults of another ascidian, S. plicata .…”

Section: Ascidiansmentioning

confidence: 99%

Use of invertebrates to model chemically induced parkinsonism-symptoms

Corrêa

Gomes

Mello

et al. 2023

Biochemical Society Transactions

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The prevalence of neurological diseases is currently growing due to the combination of several factor, including poor lifestyle and environmental imbalance which enhance the contribution of genetic factors. Parkinson's disease (PD), a chronic and progressive neurological condition, is one of the most prevalent neurodegenerative human diseases. Development of models may help to understand its pathophysiology. This review focuses on studies using invertebrate models to investigate certain chemicals that generate parkinsonian-like symptoms models. Additionally, we report some preliminary results of our own research on a crustacean (the crab Ucides cordatus) and a solitary ascidian (Styela plicata), used after induction of parkinsonism with 6-hydroxydopamine and the pesticide rotenone, respectively. We also discuss the advantages, limits, and drawbacks of using invertebrate models to study PD. We suggest prospects and directions for future investigations of PD, based on invertebrate models.

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Novel insights about the ascidian dopamine system: Pharmacology and phylogenetics of catecholaminergic receptors on the Phallusia nigra immune cells

Cited by 6 publications

References 39 publications

A Miniaturized Nigrostriatal-Like Circuit Regulating Locomotor Performance in a Protochordate

A Miniaturized Nigrostriatal-Like Circuit Regulating Locomotor Performance in a Protochordate

Comprehensive analysis of behavioral dynamics in the protochordateCiona intestinalis

Use of invertebrates to model chemically induced parkinsonism-symptoms

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