Novel insight into biological activity and phytochemical composition of Sorbus aucuparia L. fruits: Fractionated extracts as inhibitors of protein glycation and oxidative/nitrative damage of human plasma components

The Effects of Sorbus aucuparia L. Fruit Extracts on Oxidative/Nitrative Modifications of Human Fibrinogen, Impact on Enzymatic Properties of Thrombin, and Hyaluronidase Activity In Vitro

“…Indeed, according to previous research, rowanberries exhibit inhibitory activity towards α-amylase and α-glucosidase, i.e., enzymes involved in the digestion of carbohydrates [ 4 , 5 ], and they turn out to be effective reducers of the sugar level in a mouse model of diabetes [ 6 ]. Moreover, rowanberry extracts were proved to inhibit the formation of advanced glycation end products [ 7 ], which are considered to be responsible for macro- and microvascular complications of diabetes [ 8 ]. Taking into account that glycation may both directly impair the function of various proteins and entail further damages to proteins and other biomolecules by increasing the production of reactive oxygen species (ROS) [ 8 ], the significant antioxidant activity of rowanberries has also been pointed out as an essential component of their health-promoting properties [ 7 ].…”

“…Moreover, rowanberry extracts were proved to inhibit the formation of advanced glycation end products [ 7 ], which are considered to be responsible for macro- and microvascular complications of diabetes [ 8 ]. Taking into account that glycation may both directly impair the function of various proteins and entail further damages to proteins and other biomolecules by increasing the production of reactive oxygen species (ROS) [ 8 ], the significant antioxidant activity of rowanberries has also been pointed out as an essential component of their health-promoting properties [ 7 ]. Among the previously observed effects of S. aucuparia fruit extracts on redox homeostasis were the ability to scavenge in vivo-generated ROS, increase the total antioxidant capacity of human plasma, and protect plasma proteins and lipids against oxidative and nitrative damage [ 7 ].…”

“…Taking into account that glycation may both directly impair the function of various proteins and entail further damages to proteins and other biomolecules by increasing the production of reactive oxygen species (ROS) [ 8 ], the significant antioxidant activity of rowanberries has also been pointed out as an essential component of their health-promoting properties [ 7 ]. Among the previously observed effects of S. aucuparia fruit extracts on redox homeostasis were the ability to scavenge in vivo-generated ROS, increase the total antioxidant capacity of human plasma, and protect plasma proteins and lipids against oxidative and nitrative damage [ 7 ]. The occurrence of a rich fraction of various polyphenolic compounds, including proanthocyanidins, pseudodepsides of caffeic and ferulic acids, and flavonols, was indicated in rowanberries as co-responsible for their antioxidant and antiglycation properties and the ability to inhibit the digestion of carbohydrates [ 4 , 5 , 7 ].…”

“…Among the previously observed effects of S. aucuparia fruit extracts on redox homeostasis were the ability to scavenge in vivo-generated ROS, increase the total antioxidant capacity of human plasma, and protect plasma proteins and lipids against oxidative and nitrative damage [ 7 ]. The occurrence of a rich fraction of various polyphenolic compounds, including proanthocyanidins, pseudodepsides of caffeic and ferulic acids, and flavonols, was indicated in rowanberries as co-responsible for their antioxidant and antiglycation properties and the ability to inhibit the digestion of carbohydrates [ 4 , 5 , 7 ]. So far, the obtained results seem to confirm the beneficial biological effects of rowan fruits and encourage more detailed studies on the bioactivity mechanisms of the tested plant material that might contribute to its functional applications.…”

“…Furthermore, multiple functions of phytochemicals on the living cells and their possible synergistic activity contributed to growing interest in applying plant-based foods in the prevention and adjuvant therapy of human diseases [ 12 ]. S. aucuparia is one of the species of interest due to its wide occurrence, the long tradition of consumption, and several reports on beneficial health properties of rowanberries and extracts derived from them [ 1 , 4 , 5 , 6 , 7 ].…”