Novel injectable and in situ cross-linkable hydrogels of dextran methacrylate and scleroglucan derivatives: Preparation and characterization

Corrente, Federica; Amara, Hend M. Abu; Pacelli, Settimio; Paolicelli, Patrizia; Casadei, Maria Antonietta

doi:10.1016/j.carbpol.2012.10.018

Cited by 28 publications

(12 citation statements)

References 22 publications

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“…While cross-linking through physical interactions such as hydrogen bonding or hydrophobic interactions has been proposed to avoid toxicity problems [11][12][13], such cross-linking may be not be strong enough to produce a sufficiently stable hydrogel for effective drug loading. Fortunately, polysaccharides may be used as chemical cross-linkers to produce biocompatible hydrogels which present attractive applications in drug delivery [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Chitosan cross-linked poly(acrylic acid) hydrogels: Drug release control and mechanism

Wang

Yuan

et al. 2017

Colloids and Surfaces B: Biointerfaces

148

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Chitosan has been used to cross-link poly(acrylic acid) to give three pH-sensitive hydrogels designed to control the release of the drugs amoxicillin and meloxicam. The extent of cross-linking and solution pH was found to dominate the swelling behavior of these hydrogels as shown by scanning electron microscopy and swelling time dependencies. The rates of release of amoxicillin and meloxicam from the loaded hydrogels increased with increase in pH consistent with the extent of hydrogen bonding between hydrogel components and between the hydrogel and the drugs being important determinants of release rate. Both the Korsemeyer-Peppas and Weibull models fitted release data consistent with drug release occurred through a combination of drug diffusion and hydrogel relaxation processes. These hydrogels appear to provide an ideal basis for controlled drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Chitosan cross-linked poly(acrylic acid) hydrogels: Drug release control and mechanism

Wang

Yuan

et al. 2017

Colloids and Surfaces B: Biointerfaces

148

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“…In situ forming hydrogels, compared with preformed hydrogels, can fill defects with all shapes, allow homogeneous incorporation of therapeutic molecules/cells and do not require surgical procedures for implantation; consequently, research efforts on biomedical applications of in situ forming hydrogels has recently increased (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of an Enzyme Mediated in situ Forming Hydrogel Based on Gum Tragacanth for Biomedical Applications

et al. 2014

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Background: The excellent biocompatibility, biodegradability and biological properties of the hydrogels, fabricated using natural polymers, especially polysaccharides, are very advantageous for biomedical applications. Gum tragacanth (GT) is a heterogeneous highly branched anionic polysaccharide, which has been used extensively in food and pharmaceutical industries. Despite, its desirable properties, the potential biomedical applications of this natural gum have not been fully explored. In this study, an enzyme catalyzed in situ forming hydrogel, based on Iranian gum tragacanth (exudate of Astragalus fluccosus) was prepared and characterized for biomedical applications. Objectives: The main objective of the present study was to explore the feasibility of using tragacanth natural gum as a base for in situforming hydrogels in biomedical applications. Materials and Methods: First, tyramine (TA) was conjugated to the water-soluble part of GT (TGA) using aqueous-phase carbodiimide activation chemistry. Next, in situ forming hydrogel was prepared via an enzyme catalyzed coupling reaction in the presence of horseradish peroxidase (HRP) and H 2 O 2. Gelation time, swelling/degradation behavior and mechanical properties of the hydrogel and cell viability of the encapsulated cells within these hydrogels were investigated. Results: The gelation time of the hydrogel was less than 30 seconds, which is very desirable for clinical applications. At concentrations ≤ 0.1% (w/v), both GT and TA-TGA showed no toxicity towards human mesenchymal stem cells (hMSCs) and Caco-2 cells. More than 90% of the encapsulated hMSCs in the hydrogels, which were prepared at H 2 O 2 concentrations of less than 15.0 mM, remained viable after 2 hours of incubation. Conclusions: The TA-TGA conjugate can be gelled enzymatically in the presence of HRP and H 2 O 2. This in situ forming hydrogel might be a desirable candidate for biomedical applications.

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“…GG-MA 4 ) was investigated for the development of injectable and photocross-linkable hydrogels as GG-MA 8 formed too brittle gels upon UV irradiation, in agreement with the results obtained with similar systems [24].…”

Section: Synthesis and Characterization Of Gg-mamentioning

confidence: 64%

Injectable and photocross-linkable gels based on gellan gum methacrylate: A new tool for biomedical application

Pacelli

Paolicelli

Dreesen

et al. 2015

International Journal of Biological Macromolecules

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Novel injectable and in situ cross-linkable hydrogels of dextran methacrylate and scleroglucan derivatives: Preparation and characterization

Cited by 28 publications

References 22 publications

Chitosan cross-linked poly(acrylic acid) hydrogels: Drug release control and mechanism

Chitosan cross-linked poly(acrylic acid) hydrogels: Drug release control and mechanism

Synthesis and Characterization of an Enzyme Mediated in situ Forming Hydrogel Based on Gum Tragacanth for Biomedical Applications

Injectable and photocross-linkable gels based on gellan gum methacrylate: A new tool for biomedical application

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