Novel Influenza D virus: Epidemiology, pathology, evolution and biological characteristics

Su, Shuo; Fu, Xinliang; Li, Gairu; Kerlin, Fiona; Veit, Michael

doi:10.1080/21505594.2017.1365216

Cited by 117 publications

(119 citation statements)

References 70 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, this is the first report of identification of IDV in western Canada. IDV was initially identified in swine in the United States, and then was found to be prevalent in cattle of the United States, Luxembourg, Ireland, France, Japan and China (Flynn et al, ; Mekata et al, ; Snoeck et al, ; Su, Fu, Li, Kerlin, & Veit, ). IDV may be an emerging pathogen in Canadian cattle; or, on the other hand, the lack of Canadian reports before may be due to the unavailability of a diagnostic assay.…”

Section: Discussionmentioning

confidence: 99%

“…IDV was also recently identified in sheep and goats (Quast et al, ). Although there is evidence that IDV can infect humans, whether it can cause disease is unclear at this point and the risk of zoonosis is considered to be low (Su et al, ). Preliminary evidence showed that IDV could be potentially associated with BRD (Mitra et al, ; Ng et al, ), and our study provided additional evidence for the role of IDV in BRD as its detection was significantly associated with BRD in single variable analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Respiratory viruses identified in western Canadian beef cattle by metagenomic sequencing and their association with bovine respiratory disease

Zhang

Hill

Fernando

et al. 2019

Transbound Emerg Dis

116

View full text Add to dashboard Cite

Bovine respiratory disease (BRD) causes considerable economic losses in North America. The pathogenesis involves interactions between bacteria, viruses, environment and management factors. Primary viral infection can increase the risk of secondary fatal bacterial infection. The objective of this study was to use metagenomic sequencing to characterize the respiratory viromes of paired nasal swabs and tracheal washes from western Canadian feedlot cattle, with or without BRD. A total of 116 cattle (116 nasal swabs and 116 tracheal washes) were analysed. The presence of influenza D virus (IDV), bovine rhinitis A virus (BRAV), bovine rhinitis B virus (BRBV), bovine coronavirus (BCV) and bovine respiratory syncytial virus (BRSV) was associated with BRD. Agreement between identification of viruses in nasal swabs and tracheal washes was generally weak, indicating that sampling location may affect detection of infection. This study reported several viruses for the first time in Canada and provides a basis for further studies investigating candidate viruses important to the prevention of BRD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Respiratory viruses identified in western Canadian beef cattle by metagenomic sequencing and their association with bovine respiratory disease

Zhang

Hill

Fernando

et al. 2019

Transbound Emerg Dis

116

View full text Add to dashboard Cite

show abstract

“…Concerns about IDV have been raised since its discovery, and it has now been found worldwide, particularly in cattle (Hause et al, ; Su, Fu, Li, Kerlin, & Veit, ). We first reported the identification of IDV in western Canada, and the prevalence was 13.8% in nasal swabs and tracheal washes from cattle with BRD (Zhang et al, ).…”

Section: Discussionmentioning

confidence: 99%

The pulmonary virome, bacteriological and histopathological findings in bovine respiratory disease from western Canada

Zhang

Hill

Godson

et al. 2019

Transbound Emerg Dis

View full text Add to dashboard Cite

The aetiology and pathogenesis of bovine respiratory disease (BRD) are complex and involve the interplay of infectious agents, management and environmental factors. Previous studies of BRD focused on ante‐mortem samples from the upper respiratory tract and identified several unconventional viruses. The lung, however, is the primary location where significant BRD lesions are usually found and is a common post‐mortem diagnostic specimen. In this study, results of high‐throughput virome sequencing, bacterial culture, targeted real‐time PCR and histological examination of 130 bovine pneumonic lungs from western Canadian cattle were combined to explore associations of microorganisms with different types of pneumonia. Fibrinous bronchopneumonia (FBP) was the predominant type of pneumonia (46.2%, 60/130) and was associated with the detection of Mannheimia haemolytica. Detection of Histophilus somni and Pasteurella multocida was associated with suppurative bronchopneumonia (SBP) and concurrent bronchopneumonia and bronchointerstitial pneumonia (BP&BIP), respectively. Sixteen viruses were identified, of which bovine parvovirus 2 (BPV2) was the most prevalent (11.5%, 15/130) followed by ungulate tetraparvovirus 1 (UTPV1, 8.5%, 11/130) and bovine respiratory syncytial virus (BRSV, 8.5%, 11/130). None of these viruses, however, were significantly associated with a particular type of pneumonia. Unconventional viruses such as influenza D virus (IDV) and bovine rhinitis B virus (BRBV) were detected, although sparsely, consistent with our previous findings in upper respiratory tract samples. Taken together, our results show that while virus detection in post‐mortem lung samples is of relatively little diagnostic value, the strong associations of H. somni and M. haemolytica with SBP and FBP, respectively, indicate that histopathology can be useful in differentiating bacterial aetiologies.

show abstract

“…Viruses that are commonly implicated include bovine herpesvirus-1 (BHV-1), bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV) and parainfluenza 3 virus (PI3V) [3]. Cattle are considered the major IDV reservoir but understanding the possible role of IDV in bovine respiratory disease (BRD) is one of the main focuses of research studies concerning this virus [4,5]. BRD is a complex pathology causing economic losses and it is linked with microbial pathogens, host, environmental and animal management factors.…”

Section: Introductionmentioning

confidence: 99%

Detection of a New Genetic Cluster of Influenza D Virus in Italian Cattle

Chiapponi

Faccini

Fusaro

et al. 2019

Viruses

View full text Add to dashboard Cite

Influenza D virus (IDV) has been increasingly reported all over the world. Cattle are considered the major viral reservoir. Based on the hemagglutinin-esterase (HEF) gene, three main genetic and antigenic clusters have been identified: D/OK distributed worldwide, D/660 detected only in the USA and D/Japan in Japan. Up to 2017, all the Italian IDV isolates belonged to the D/OK genetic cluster. From January 2018 to May 2019, we performed virological surveillance for IDV from respiratory outbreaks in 725 bovine farms in Northern Italy by RT-PCR. Seventy-four farms were positive for IDV. A full or partial genome sequence was obtained from 29 samples. Unexpectedly, a phylogenetic analysis of the HEF gene showed the presence of 12 strains belonging to the D/660 cluster, previously unreported in Europe. The earliest D/660 strain was collected in March 2018 from cattle imported from France. Moreover, we detected one viral strain with a reassortant genetic pattern (PB2, PB1, P42, HEF and NP segments in the D/660 cluster, whilst P3 and NS segments in the D/OK cluster). These results confirm the circulation of IDV in the Italian cattle population and highlight the need to monitor the development of the spreading of this influenza virus in order to get more information about the epidemiology and the ecology of IDV viruses.

show abstract

Novel Influenza D virus: Epidemiology, pathology, evolution and biological characteristics

Cited by 117 publications

References 70 publications

Respiratory viruses identified in western Canadian beef cattle by metagenomic sequencing and their association with bovine respiratory disease

Respiratory viruses identified in western Canadian beef cattle by metagenomic sequencing and their association with bovine respiratory disease

The pulmonary virome, bacteriological and histopathological findings in bovine respiratory disease from western Canada

Detection of a New Genetic Cluster of Influenza D Virus in Italian Cattle

Contact Info

Product

Resources

About