Novel influenza A (H1N1) infection: chest CT findings from 21 cases in Seoul, Korea

Shim, Sung Shin; Kim, Y.; Ryu, Yon Ju

doi:10.1016/j.crad.2010.07.011

Cited by 17 publications

(18 citation statements)

References 19 publications

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“…Previous studies on patients with S-OIV or scrub typhus have reported that almost all patients have GGO (2,3,5,10,16,18). Our results are consistent with them.…”

Section: Discussionsupporting

confidence: 96%

“…On June 11, 2009, WHO declared the S-OIV infection to be a global pandemic (11). According to an announcement by WHO, much of the temperate northern hemisphere has passed the peak of autumn and winter pandemic influenza activity, which occurred between late October and late November 2009 (3). The results of this study also showed that a sharp peak in the number of cases occurred during this time.…”

Section: Discussionmentioning

confidence: 68%

See 1 more Smart Citation

High-resolution computed tomography findings of swine-origin influenza A (H1N1) virus (S-OIV) infection: comparison with scrub typhus

Jo¹,

Lee²,

et al. 2012

Acta Radiol

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There was considerable overlap in HRCT findings between S-OIV infection and scrub typhus. However, S-OIV showed a distinctive peribronchovascular distribution of GGO lesions. Consolidation and bronchial wall thickening were seen more frequently in S-OIV infection, whereas interlobular septal thickening and axillary lymphadenopathy were more common in scrub typhus. Thus, CT could be helpful for differential diagnosis between S-OIV infection and scrub typhus.

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“…Previous studies on patients with S-OIV or scrub typhus have reported that almost all patients have GGO (2,3,5,10,16,18). Our results are consistent with them.…”

Section: Discussionsupporting

confidence: 96%

Section: Discussionmentioning

confidence: 68%

High-resolution computed tomography findings of swine-origin influenza A (H1N1) virus (S-OIV) infection: comparison with scrub typhus

Jo¹,

Lee²,

et al. 2012

Acta Radiol

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“…In comparison to human CT imaging studies of influenza, the molecular images in the ferret show strong similarity. CT findings in patients with confirmed influenza infection show patchy ground-glass opacities in segmental multifocal distributions, mixed with areas of consolidation in the lung [12,25,45]. Moreover, the few case reports of human influenza in which lungs were imaged by [ 18 F]-FDG PET demonstrate areas of high uptake in these ground-glass opacities and consolidation [31].…”

Section: Discussionmentioning

confidence: 99%

Molecular Imaging Reveals a Progressive Pulmonary Inflammation in Lower Airways in Ferrets Infected with 2009 H1N1 Pandemic Influenza Virus

Jonsson

Camp

et al. 2012

PLoS ONE

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Molecular imaging has gained attention as a possible approach for the study of the progression of inflammation and disease dynamics. Herein we used [18F]-2-deoxy-2-fluoro-D-glucose ([18F]-FDG) as a radiotracer for PET imaging coupled with CT (FDG-PET/CT) to gain insight into the spatiotemporal progression of the inflammatory response of ferrets infected with a clinical isolate of a pandemic influenza virus, H1N1 (H1N1pdm). The thoracic regions of mock- and H1N1pdm-infected ferrets were imaged prior to infection and at 1, 2, 3 and 6 days post-infection (DPI). On 1 DPI, FDG-PET/CT imaging revealed areas of consolidation in the right caudal lobe which corresponded with elevated [18F]-FDG uptake (maximum standardized uptake values (SUVMax), 4.7–7.0). By days 2 and 3, consolidation (CT) and inflammation ([18F]-FDG) appeared in the left caudal lobe. By 6 DPI, CT images showed extensive areas of patchy ground-glass opacities (GGO) and consolidations with the largest lesions having high SUVMax (6.0–7.6). Viral shedding and replication were detected in most nasal, throat and rectal swabs and nasal turbinates and lungs on 1, 2 and 3 DPI, but not on day 7, respectively. In conclusion, molecular imaging of infected ferrets revealed a progressive consolidation on CT with corresponding [18F]-FDG uptake. Strong positive correlations were measured between SUVMax and bronchiolitis-related pathologic scoring (Spearman’s ρ = 0.75). Importantly, the extensive areas of patchy GGO and consolidation seen on CT in the ferret model at 6 DPI are similar to that reported for human H1N1pdm infections. In summary, these first molecular imaging studies of lower respiratory infection with H1N1pdm show that FDG-PET can give insight into the spatiotemporal progression of the inflammation in real-time.

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“…Although the general radiological findings of thoracic S-OIV manifestation have been described in previous reports [13,14,15,16,17,18], hardly any attention was paid to the subset of immunocompromised patients [8,9] who were described as a high-risk group for S-OIV infection and a more severe course [7,19]. Therefore, the present report has shown the importance of MDCT findings and their relevance in this special high-risk patient population.…”

Section: Discussionmentioning

confidence: 96%

Pulmonary Manifestation of Novel Swine-Origin Influenza A (H1N1) Virus (S-OIV) Infection in Immunocompromised Patients: Initial Findings with Multidetector Computed Tomography

2012

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Objective: To describe initial multidetector computed tomographic (MDCT) findings of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients and to evaluate whether or not identification of certain abnormalities can help predict patients who are at risk for a severe clinical course. Subjects and Methods: This retrospective study included 13 patients with confirmed S-OIV infection suffering from an underlying immunodeficiency or who were receiving immunosuppressive therapy. All patients underwent MDCT of the thorax due to respiratory distress. All data were read by two independent radiologists who described the type and pattern of opacities, distribution and extent of the abnormalities observed. Adverse outcome measures were defined as acute respiratory distress syndrome with the need for mechanical ventilation, extracorporeal membrane oxygenation or death. Results: MDCT revealed pulmonary manifestations in 12 (92%) of 13 individuals. Six (50%) patients showed an adverse outcome with development of acute respiratory distress syndrome, 4 of these died. The most common findings were ground-glass opacities (10/12; 83%) and pulmonary consolidation (7/12; 58%) predominantly with a bilateral distribution. Reticular pattern and a tree-in-bud appearance were found in 3/12 (25%), respectively. Bilateral opacities with extensive involvement of the lung parenchyma were most predictive of a severe clinical course. Conclusion: The MDCT scan in immunocompromised patients with confirmed S-OIV infection frequently revealed pulmonary abnormalities, which included ground-glass opacities and consolidations. Therefore, prediction of an adverse clinical outcome could be made in patients with MDCT findings demonstrating bilateral extensive consolidations, often combined with ground-glass opacities.

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Novel influenza A (H1N1) infection: chest CT findings from 21 cases in Seoul, Korea

Cited by 17 publications

References 19 publications

High-resolution computed tomography findings of swine-origin influenza A (H1N1) virus (S-OIV) infection: comparison with scrub typhus

High-resolution computed tomography findings of swine-origin influenza A (H1N1) virus (S-OIV) infection: comparison with scrub typhus

Molecular Imaging Reveals a Progressive Pulmonary Inflammation in Lower Airways in Ferrets Infected with 2009 H1N1 Pandemic Influenza Virus

Pulmonary Manifestation of Novel Swine-Origin Influenza A (H1N1) Virus (S-OIV) Infection in Immunocompromised Patients: Initial Findings with Multidetector Computed Tomography

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