Novel infection-resistant surface coatings: A bioengineering approach

Khoo, Xiaojuan; Grinstaff, Mark W.

doi:10.1557/mrs.2011.66

Cited by 36 publications

(35 citation statements)

References 136 publications

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“…107 These and other strategies for preventing bacterial attachment have recently been reviewed in depth. 84, 90, 108 A shift away from materials that prevent cell attachment to materials that enhance growth may provide insight into the properties of surfaces sensed by bacteria and the biological machinery that is involved in this process.…”

Section: Cell Attachment To Different Classes Of Materialsmentioning

confidence: 99%

Bacteria–surface interactions

2013

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The interaction of bacteria with surfaces has important implications in a range of areas, including bioenergy, biofouling, biofilm formation, and the infection of plants and animals. Many of the interactions of bacteria with surfaces produce changes in the expression of genes that influence cell morphology and behavior, including genes essential for motility and surface attachment. Despite the attention that these phenotypes have garnered, the bacterial systems used for sensing and responding to surfaces are still not well understood. An understanding of these mechanisms will guide the development of new classes of materials that inhibit and promote cell growth, and complement studies of the physiology of bacteria in contact with surfaces. Recent studies from a range of fields in science and engineering are poised to guide future investigations in this area. This review summarizes recent studies on bacteria-surface interactions, discusses mechanisms of surface sensing and consequences of cell attachment, provides an overview of surfaces that have been used in bacterial studies, and highlights unanswered questions in this field.

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Section: Cell Attachment To Different Classes Of Materialsmentioning

confidence: 99%

Bacteria–surface interactions

2013

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“…Bacterial attachment at this initial stage is, by all means, a complex process that is governed by multiple cell-surface interactions. These interactions can be greatly influenced by surface chemistry (functional groups, electrostatic charge, coatings), surface energy (as related to the surface hydrophobicity), mechanical properties (elastic modulus, shear forces), environmental conditions (pH, temperature, nutrient levels, competing organisms), surface topography, as well as bacterial surface structures (pili, flagella, fimbriae, adhesins) [7][8][9][10][11][12][13][14][15][16][17][18]. Cell attachment to surfaces is governed by a combination of all these factors (surface properties, environmental conditions, and cell physiology), making it virtually impossible to uncouple the influence of individual factors.…”

Section: Surface Attachment and Biofilm Formationmentioning

confidence: 99%

Nano and Microscale Topographies for the Prevention of Bacterial Surface Fouling

2014

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Bacterial surface fouling is problematic for a wide range of applications and industries, including, but not limited to medical devices (implants, replacement joints, stents, pacemakers), municipal infrastructure (pipes, wastewater treatment), food production (food processing surfaces, processing equipment), and transportation (ship hulls, aircraft fuel tanks). One method to combat bacterial biofouling is to modify the topographical structure of the surface in question, thereby limiting the ability of individual cells to attach to the surface, colonize, and form biofilms. Multiple research groups have demonstrated that micro and nanoscale topographies significantly reduce bacterial biofouling, for both individual cells and bacterial biofilms. Antifouling strategies that utilize engineered topographical surface features with well-defined dimensions and shapes have demonstrated a greater degree of controllable inhibition over initial cell attachment, in comparison to undefined, texturized, or porous surfaces. This review article will explore the various approaches and techniques used by researches, including work from our own group, and the underlying physical properties of these highly structured, engineered micro/nanoscale topographies that significantly impact bacterial surface attachment.

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“…Investigating changes in bacterial metabolomes in response to the different surfaces (e.g., metals and polymers) may contribute to the development of novel materials resistant to biofilm formation [248,249]. Coating or embedding medical devices with antibiotics is a common approach to prevent biofilm infections, but the overuse of antibiotics incurs the risk of inducing the rapid development of resistance [250,251]. …”

Section: Analysis Of Biofilms With Nmr-based Metabolomicsmentioning

confidence: 99%

Analysis of Bacterial Biofilms Using NMR-Based Metabolomics

Zhang

Powers²

2012

Future Med. Chem.

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Infectious diseases can be difficult to cure, especially if the pathogen forms a biofilm. After decades of extensive research into the morphology, physiology and genomics of biofilm formation, attention has recently been directed toward the analysis of the cellular metabolome in order to understand the transformation of a planktonic cell to a biofilm. Metabolomics can play an invaluable role in enhancing our understanding of the underlying biological processes related to the structure, formation and antibiotic resistance of biofilms. A systematic view of metabolic pathways or processes responsible for regulating this ‘social structure’ of microorganisms may provide critical insights into biofilm-related drug resistance and lead to novel treatments. This review will discuss the development of NMR-based metabolomics as a technology to study medically relevant biofilms. Recent advancements from case studies reviewed in this manuscript have shown the potential of metabolomics to shed light on numerous biological problems related to biofilms.

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Novel infection-resistant surface coatings: A bioengineering approach

Abstract: Abstract

Cited by 36 publications

References 136 publications

Bacteria–surface interactions

Bacteria–surface interactions

Nano and Microscale Topographies for the Prevention of Bacterial Surface Fouling

Analysis of Bacterial Biofilms Using NMR-Based Metabolomics

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