Novel indanone-chalcone esters with potential anti-Alzheimer effects designed using hybridization and bioisosteric replacement approaches

A recent update on huprine and its hybrids as a potential multifunctional agent for the treatment of Alzheimer's disease

“…The reduced level of ACh is believed to be the main cause for disease related signs such as loss of memory and cognitive functions (Czarnecka et al, 2023). Therefore, ACh balance is an central therapeutic approach for AD, and ChE inhibitors are one important therapeutic target for AD (Alzweiri et al, 2022;Azimian et al, 2023;Davis & Eckroat, 2021;Estolano-Cobián et al, 2020;He et al, 2021;Sari & Yilmaz, 2021;Suwanhom et al, 2020).…”