Novel In Situ Gelling Hydrogels Loaded with Recombinant Collagen Peptide Microspheres as a Slow‐Release System Induce Ectopic Bone Formation

Fahmy-Garcia, Shorouk; Mumcuoglu, Didem; Miguel, Laura De; Dieleman, Veerle; Witte-Bouma, Janneke; Eerden, Bram C. J. van der; Driel, Marjolein van; Eglin, David; Verhaar, Jan A N; Kluijtmans, Sebastiaan G. J. M.; Osch, Gerjo J.V.M. van; Farrell, Eric

doi:10.1002/adhm.201801496

Cited by 10 publications

(6 citation statements)

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“…S5), and the molar percentage of peptide graft was 18.5%. Collagen peptide (COL-P) is the product of enzymatic hydrolysis of collagen, which could promote cell proliferation, migration, and thus may accelerate the wound healing (40). Then, the peptide conformation in HA-P and GM-P polymers was investigated by circular dichroism (CD) analysis.…”

Section: Preparation and Characterization Of Glycopeptide Gm-p And Ha-pmentioning

confidence: 99%

ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus –infected chronic skin wound healing

et al. 2022

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The treatment of difficult-to-heal wounds remains a substantial clinical challenge due to deteriorative tissue microenvironment including the loss of extracellular matrix (ECM), excessive inflammation, impaired angiogenesis, and bacterial infection. Inspired by the chemical components, fibrous structure, and biological function of natural ECM, antibacterial and tissue environment–responsive glycopeptide hybrid hydrogel was developed for chronic wound healing. The hydrogel can facilitate the cell proliferation and macrophage polarization to M2 phenotype, and show potent antibacterial efficacy against both Gram-negative and Gram-positive bacteria. Significantly, the glycopeptide hydrogel accelerated the reconstruction of methicillin-resistant Staphylococcus aureus (MRSA)–infected full-thickness diabetic and scalding skin by orchestrating a pro-regenerative response indicated by abundant M2-type macrophages, attenuated inflammation, and promoted angiogenesis. Collectively, ECM-mimetic and immunomodulatory glycopeptide hydrogel is a promising multifunctional dressing to reshape the damaged tissue environment without additional drugs, exogenous cytokines, or cells, providing an effective strategy for the repair and regeneration of chronic cutaneous wounds.

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Section: Preparation and Characterization Of Glycopeptide Gm-p And Ha-pmentioning

confidence: 99%

ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus –infected chronic skin wound healing

et al. 2022

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“…[ 130 ] Among all BMPs, BMP‐2 and rhBMP‐2 are the most widely applied, and their incorporation into hydrogel systems for bone regeneration has been the focus of research in recent years. [ 131–154 ] Some basic studies investigating the effects of different variables of the delivery systems (e.g., BMP‐2 administration dose, [ 148,155–157 ] implantation site, [ 158 ] physical properties, [ 159–161 ] and crosslinking chemistry of the hydrogel matrices [ 132,162 ] ) on the therapeutic efficacy have also been reported. These studies may serve as references for improving BMP‐2 delivery in hydrogel systems for bone regeneration.…”

Section: Hydrogel‐based Growth Factor Delivery Strategiesmentioning

confidence: 99%

Hydrogel‐Based Growth Factor Delivery Platforms: Strategies and Recent Advances

Shan

2023

Advanced Materials

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Growth factors play a crucial role in regulating a broad variety of biological processes and have been regarded as powerful therapeutic agents in tissue engineering and regenerative medicine in the past decades. However, their application is limited by their short half‐lives and potential side effects in physiological environments. Hydrogels have been identified as having the promising potential to prolong the half‐lives of growth factors and mitigate their adverse effects by restricting them within the matrix to reduce their rapid proteolysis, burst release, and unwanted diffusion. This review discusses recent progress in the development of growth factor‐containing hydrogels for various biomedical applications, including wound healing, brain tissue repair, cartilage and bone regeneration, and spinal cord injury repair. In addition, the review introduces strategies for optimizing growth factor releases including affinity‐based delivery, carrier‐assisted delivery, stimuli‐responsive delivery, spatial structure‐based delivery, and cellular system‐based delivery. Finally, the review presents current limitations and future research directions for growth factor‐delivering hydrogels.This article is protected by copyright. All rights reserved

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“…For instance, the incorporation of recombinant collagen peptide microspheres into alginate hydrogels enabled in situ gelation and delivery of BMP-2, inducing bone formation. 138 However, the application of hydrogels for delivering recombinant proteins with immunomodulatory activity in bone repair remains limited, warranting further research in this area. The delivery of biologics using hydrogels shows significant promise due to the highly compatible nature of hydrogels with nucleic acids and proteins, which are susceptible to environmental conditions.…”

Section: Delivery Of Biologicsmentioning

confidence: 99%

Section: Local Delivery Hydrogels To Restore Immune Homeostasismentioning

confidence: 99%

Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration

Xiong

Zha

et al. 2023

Biomater. Sci.

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Novel In Situ Gelling Hydrogels Loaded with Recombinant Collagen Peptide Microspheres as a Slow‐Release System Induce Ectopic Bone Formation

Cited by 10 publications

References 0 publications

ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus –infected chronic skin wound healing

ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus –infected chronic skin wound healing

Hydrogel‐Based Growth Factor Delivery Platforms: Strategies and Recent Advances

Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration

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