Novel in situ forming hydrogel based on xanthan and chitosan re-gelifying in liquids for local drug delivery

Huang, Jinjian; Deng, Youming; Ren, Jianan; Chen, Guopu; Wang, Gefei; Wang, Feng; Wu, Xiuwen

doi:10.1016/j.carbpol.2018.01.025

Cited by 127 publications

(64 citation statements)

References 36 publications

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“…It was observed that collagen was deposited in an orderly manner and there was an increase in the natural hyaluronic acid at the lesion site . Multinuclear giant cells were absent, indicating that these chitosan‐based hydrogels would not cause severe foreign body reactions . Moreover, the inflammation of surrounding tissues was relieved by chitosan‐based hydrogel implantations.…”

Section: Physicochemical Properties Of Chitosan‐based Hydrogels and Tmentioning

confidence: 99%

“…Evidently, the porosity is a determined parameter because it provides the required oxygen and nutrition for chromosome segregation and cell membrane split. Moreover, the diameters of pores are changeable for the same hydrogels . However, their sizes seem to have limited impact on the 3D cell culture.…”

Section: Physicochemical Properties Of Chitosan‐based Hydrogels and Tmentioning

confidence: 99%

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Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Section: Physicochemical Properties Of Chitosan‐based Hydrogels and Tmentioning

confidence: 99%

Section: Physicochemical Properties Of Chitosan‐based Hydrogels and Tmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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“…Hydrogel scaffolds are generated from the crosslinking of polymers (Huang, Deng, et al, ; Huang, Ren, et al, ). Based on the types polymers extracted, the hydrogels can be classified into natural hydrogels and synthetic hydrogels.…”

Section: Biomaterials For Intestinal Organoid Culturementioning

confidence: 99%

Biomaterials and biosensors in intestinal organoid culture, a progress review

Huang

Jiang

Ren

et al. 2020

J Biomedical Materials Res

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As an emerging technology, intestinal organoids are promising new tools for basic and translational research in gastroenterology. Currently, culture of intestinal organoids relies mostly on a type of tumor-derived scaffolds, namely Matrigel, which may pose tumorigenic risks to organoid implantation. Apart from the traditional detection methods, such as tissue slicing and fluorescence staining, the monitoring of intestinal organoids requires real-time biosensors that can adapt to their threedimensional dynamic growth patterns. In this review, we summarized the recent advances in developing definite hydrogel scaffolds for intestinal organoid culture and identified key parameters for scaffold design. In addition, classified by different substrate compositions like pH, electrolytes, and functional proteins, we concluded the existing live-imaging biosensors and elucidated their underlying mechanisms. We hope this review enhances the understanding of intestinal organoid culture and provides more practical approaches to investigate them. K E Y W O R D Sbiosensor, intestinal stem cell, organoid, regenerative medicine, scaffold design

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“…These hydrogels are able to release the drug at the desired time under external stimulation in a specific site. The application in drug delivery of hydrogels is particularly beneficial in preventing drug degradation and avoiding some shortcomings such as poor water solubility or short‐life‐cycle at the interface . Hydrogels possess less side effects, efficient drug utilization, accurate drug targeting toward specific sites, and low cost in a drug delivery system …”

Section: Biomedical Applications Of Polysaccharides and Polysaccharidmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

260

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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Novel in situ forming hydrogel based on xanthan and chitosan re-gelifying in liquids for local drug delivery

Cited by 127 publications

References 36 publications

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Biomaterials and biosensors in intestinal organoid culture, a progress review

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

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