Novel Imputing Method and Deep Learning Techniques for Early Prediction of Sepsis in Intensive Care Units

Abstract

It is possible to exploit the predictive capacity of data collected in intensive care units (ICU) with a high ratio of missing values. Combining several sources of information, a considerable number of missing values are generated. In this manuscript, an alternative approach to impute this type of data, together with the use of deep learning techniques to improve the early detection of sepsis in ICU is proposed. Initially, laboratory tests are separated and summarized. Then, their most representative information is extracted by taking codes from an autoencoder. This information is combined with the rest of the variables and used to exploit temporal dependencies through long short-term memory recurrent neural networks. With the proposed approach our team, WIN-UAB, was ranked in the position 38/78 with a utility score (defined in the the PhysioNet/Computing in Cardiology Challenge 2019) of 0.241 on the full test set. The predictive capacity of the proposed solution demonstrated the potential of integrating an alternative approach for imputing variables with a high ratio of missing values. In terms of dimensionality reduction, it is possible to reduce 27% of features through the codes of autoencoders.

Desafios e Tendências na Predição de Sepse

“…Foi estranho ver apenas um trabalho [Macias 2019] explorando técnicas do tipo LSTM visto que sua especialidade é trabalhar com séries temporais, o que é desejado pela predição de sepse para estruturar melhor os dados clínicos dos pacientes em intervalos regulares. Isso talvez também possa ser explicado por [Norrie 2018][Wang 2020] que diz respeito à dificuldade de implementação e aceitação de modelos complexos por parte da comunidade médica.…”

Comparative Study of Machine Learning Models for Onset Sepsis Prediction

“…Macias et al [26] proposed a model based on LSTM. The missing values were handled through a window of N hours, if one value is inside the window then the missing value is replaced by it, if more than one value is found inside the window then the missing value is replaced by their mean.…”

Sensor Data Prediction in Missile Flight Tests

“…Predicting sensor data can reduce costs and make up for compromised or faulty sensors, so the needs are increasing in many areas. Examples are the prediction of temperature in the industry [ 1 ], health-related applications [ 2 ], and the pandemic of COVID-19 [ 3 ].…”