“…The metal complexes of imine-linked receptors have been extensively reported because of their pronounced application in research arena of catalysis, biology, mimicking, sensing, and materials science. − These metal complexes have gained the real impulse in last two decades, when materials were explored comprehensively for modulation of surface area, porous nature, and labile metal–ligand interactions. − In this context, multinuclear metal complexes are reported, which mimics the metalloenzyme for their catalytic function such as urease, phosphotase, hemerythrin, catechol oxidase, arginase, ribonuclease reductase. − Similarly, nowadays these metal complexes are intensively being used for sensing of anions, biomolecules, and organophosphate with better optical and electrochemical properties. − The sensing in aqueous medium is a challenging task due to competition between the solvent and guest for receptor binding sites, and the issue is very severe, if the binding is realized with hydrogen bonding. − To address this problem of sensing in aqueous medium, the transition metal complexes have gained good reputation through utilizing electrostatic interaction, vacant d-orbital to form covalent bond or sometimes replacement of labile ligand. , The strategy is explored reasonably; however, many reports are limited to anion sensing only. Contrarily, these activities are applied hardly to warfare chemicals, poisonous materials such as nerve agents, and organophosphates.…”