Novel imidazo[1,2-c]pyrimidine base-modified nucleosides: synthesis and antiviral evaluation

Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics

“…These new nucleobase modified 2’-deoxycytidine analogues can be used in the synthesis [29,33–34] of modified DNA oligomers for further studies of the TET-mediated processes which are of great importance in the emerging field of epigenetics. In addition they could find application as novel antivirals and/or as antimetabolites [35–36]. The majority of the obtained compounds contain functionalized side chains thus allowing further manipulations.…”

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

“…An additional crop was obtained by extracting the inorganic residue with chloroform which upon concentration yielded the same product. Yield (50%); recrystallized from methanol as yellow crystals; Rf: 0.74 (n-hexane-ethyl acetate; 2:1; v/v); mp 147-148 °C; IR (KBr) cm (9). A solution of compound 8 (0.767 mmoL) was heated with aqueous acetic acid (150 mL, 10%) under reflux for 8 h After cooling the 2',3'-diol 9 that separated out was filtered off, washed with water and dried.…”

“…A number of nucleoside analogues have been found to show a broad spectrum of biological effects such as antifungal [1,2], antibacterial [1][2][3], antitumor [3][4][5], antiviral [3,4,[6][7][8][9][10][11][12][13][14] anti-inflammatory [15] and analgesic [15] activities. Moreover, 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogues have showed promising activity against HCV replication [16].…”

Synthesis and Antimicrobial Activities of Benzothiophene Derivatives

“…The pyrimidine nucleus occurs in biologically important products such as nucleic acids, vitamins, coenzymes and pharmacologically useful products of plant origin. With the intention to synthesize more potent antimicrobial agents, the pyrimidine moiety has been condensed with different types of heterocycles such as furan 7 , thiophene 8 , pyrrole 9 , pyrazole [10][11] , thiazole 12 , imidazole [13][14] , pyrazine 15 and indole 16 etc. Further to our search for new antimicrobial agents we report herein the preparation of new isoxazoline, pyrimidine and pyrazoline chalcone derivatives from 4-acetylphenyl-3-chloro-1-benzothiophene-2-carboxamide compound.…”

“…H-NMR and 13 C-NMR were obtained in DMSO-d 6 at 400 MHz for 1 H nuclei and 100 MHz for 13 C nuclei (Varian Company, USA). All chemical shifts were reported in parts per million (ppm) using residual proton or carbon signal in deuterated solvents as internal references.…”