Novel imaging and related techniques for studies of diseases of the central nervous system: a review

Dai, Zhenfeng; Sun, Yi; Zhao, Xin; Pu, Xiaoping

doi:10.1007/s00441-020-03183-z

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…MALDI‐IMS allows mapping individual molecules in tissue sections with high resolution [28]. We have now identified by MALDI‐IMS specific lipid patterns for each region in healthy and AKI kidneys.…”

Section: Discussionmentioning

confidence: 99%

Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury

Martín-Saiz

Guerrero-Mauvecin

Martín‐Sánchez

et al. 2022

The Journal of Pathology

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Ferroptosis, a form of regulated necrosis characterized by peroxidation of lipids such as arachidonic acid‐containing phosphatidylethanolamine (PE), contributes to the pathogenesis of acute kidney injury (AKI). We have characterized the kidney lipidome in an experimental nephrotoxic AKI induced in mice using folic acid and assessed the impact of the ferroptosis inhibitor Ferrostatin‐1. Matrix‐assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) was used to assess kidney lipidomics and it discriminated between glomeruli, medulla, and cortex in control kidneys, AKI kidneys, and AKI + Ferrostatin‐1 kidneys. Out of 139 lipid species from 16 classes identified, 29 (20.5%) showed significant differences between control and AKI at 48 h. Total PE and lyso‐sulfatide species decreased, while phosphatidylinositol (PI) species increased in AKI. Dysregulated mRNA levels for Pemt, Pgs1, Cdipt, and Tamm41, relevant to lipid metabolism, were in line with the lipid changes observed. Ferrostatin‐1 prevented AKI and some AKI‐associated changes in lipid levels, such as the decrease in PE and lyso‐sulfatide species, without changing the gene expression of lipid metabolism enzymes. In conclusion, changes in the kidney lipid composition during nephrotoxic AKI are associated with differential gene expression of lipid metabolism enzymes and are partially prevented by Ferrostatin‐1. © 2022 The Pathological Society of Great Britain and Ireland.

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Section: Discussionmentioning

confidence: 99%

Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury

Martín-Saiz

Guerrero-Mauvecin

Martín‐Sánchez

et al. 2022

The Journal of Pathology

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How Can We Use Mathematical Modeling of Amyloid-β in Alzheimer’s Disease Research and Clinical Practices?

Chu,

Low,

et al. 2024

JAD

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The accumulation of amyloid-β (Aβ) plaques in the brain is considered a hallmark of Alzheimer’s disease (AD). Mathematical modeling, capable of predicting the motion and accumulation of Aβ, has obtained increasing interest as a potential alternative to aid the diagnosis of AD and predict disease prognosis. These mathematical models have provided insights into the pathogenesis and progression of AD that are difficult to obtain through experimental studies alone. Mathematical modeling can also simulate the effects of therapeutics on brain Aβ levels, thereby holding potential for drug efficacy simulation and the optimization of personalized treatment approaches. In this review, we provide an overview of the mathematical models that have been used to simulate brain levels of Aβ (oligomers, protofibrils, and/or plaques). We classify the models into five categories: the general ordinary differential equation models, the general partial differential equation models, the network models, the linear optimal ordinary differential equation models, and the modified partial differential equation models (i.e., Smoluchowski equation models). The assumptions, advantages and limitations of these models are discussed. Given the popularity of using the Smoluchowski equation models to simulate brain levels of Aβ, our review summarizes the history and major advancements in these models (e.g., their application to predict the onset of AD and their combined use with network models). This review is intended to bring mathematical modeling to the attention of more scientists and clinical researchers working on AD to promote cross-disciplinary research.

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Novel imaging and related techniques for studies of diseases of the central nervous system: a review

Cited by 2 publications

References 48 publications

Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury

Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury

How Can We Use Mathematical Modeling of Amyloid-β in Alzheimer’s Disease Research and Clinical Practices?

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