Novel imaging and biophysical approaches to study tissue hydraulics in mammalian folliculogenesis
Jake Turley,
Kim Whye Leong,
Chii Jou Chan
Abstract:A key developmental stage in mammalian folliculogenesis is the formation of a fluid-filled lumen (antrum) prior to ovulation. While it has long been speculated that the follicular fluid is essential for oocyte maturation and ovulation, little is known about the morphogenesis and the mechanisms driving the antrum formation and ovulation, potentially due to challenges in imaging tissue dynamics in large tissues. Misregulation of such processes leads to anovulation, a hallmark of infertility in ageing and disease… Show more
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