Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice

Seto, Sai Wang; Lam, Tsun Ip; Tam, HL; Au, Agnes; Chan, Shun‐Wan; Wu, JH; Yu, Phf H. F.; Leung, Gph; Ngai, SM; Yeung, Jhk H. K.; Leung, Ps S.; Lee, Smy M. Y.; Kwan, Yiu Wa

doi:10.1016/j.phymed.2008.10.004

Cited by 108 publications

(70 citation statements)

References 20 publications

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“…The improvements in blood cholesterol and triglyceride levels could be due to the reduced blood glucose levels in diabetic rats (Jain, Rains, & Croad, 2007;Yang, Wilson, Cho, & Song, 2004). Previous studies discovered that G. lucidum consumption caused a marked suppression of the elevated total cholesterol levels, which might be responsible for, or be associated with the inhibition of the hepatic phosphoenolpyru- vate carboxykinase gene expression (Seto et al, 2009). HMG CoA reductase activities, lipoprotein metabolism might also contribute to hypolipemia effects after GLP treatment similar to other plant medicines (Lemhadri, Hajji, Michel, & Eddouks, 2006;Sharma, Nasir, Prabhu, Murthy, & Dev, 2003).…”

Section: Resultsmentioning

confidence: 99%

Attenuating effects of Ganoderma lucidum polysaccharides on myocardial collagen cross-linking relates to advanced glycation end product and antioxidant enzymes in high-fat-diet and streptozotocin-induced diabetic rats

Meng

Zhu

Yang

et al. 2011

Carbohydrate Polymers

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Section: Resultsmentioning

confidence: 99%

Attenuating effects of Ganoderma lucidum polysaccharides on myocardial collagen cross-linking relates to advanced glycation end product and antioxidant enzymes in high-fat-diet and streptozotocin-induced diabetic rats

Meng

Zhu

Yang

et al. 2011

Carbohydrate Polymers

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“…These substances are known to have many biological activities, including anti-tumor (2), immunomodulatory (3), anti-viral (4), anti-hepatitis (5), antioxidant (6), antihypertensive (7,8) and anti-diabetic activities (9). It has been reported that Ganoderma lucidum extracts can inhibit tumor formation and the proliferation of breast and prostate cancer, hepatoma, melanoma lymphoma and myeloid leukemia cell lines (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin

Zhao

Ye²,

Fu³

et al. 2011

Int J Oncol

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Abstract. Ganoderma lucidum is a herbal mushroom known to have many health benefits, including the inhibition of tumor cell growth. However, the effect of Ganoderma lucidum on epithelial ovarian cancer (EOC), the most fatal gynecological malignancy, has not yet been reported. In this study, we determined whether Ganoderma lucidum regulates EOC cell activity. Using several cell lines derived from EOC, we found that Ganoderma lucidum strongly decreased cell numbers in a dose-dependent manner. Ganoderma lucidum also inhibited colony formation, cell migration and spheroid formation. In particular, Ganoderma lucidum was effective in inhibiting cell growth in both chemosensitive and chemoresistant cells and the treatment with Ganoderma lucidum significantly enhanced the effect of cisplatin on EOC cells. Furthermore, Ganoderma lucidum induced cell cycle arrest at the G2/M phase and also induced apoptosis by activating caspase 3. Finally, Ganoderma lucidum increased p53 but inhibited Akt expression. Taken together, these findings suggest that Ganoderma lucidum exerts multiple anti-tumor effects on ovarian cancer cells and can enhance the sensitivity of EOC cells to cisplatin. IntroductionGanoderma lucidum is a herbal mushroom that has been widely used in preventive medicines in China and other Asian countries for over 2,000 years. It has also become a popular dietary supplement in Western countries. Ganoderma lucidum contains many different bioactive compounds, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements (1).These substances are known to have many biological activities, including anti-tumor (2), immunomodulatory (3), anti-viral (4), anti-hepatitis (5), antioxidant (6), antihypertensive (7,8) and anti-diabetic activities (9). It has been reported that Ganoderma lucidum extracts can inhibit tumor formation and the proliferation of breast and prostate cancer, hepatoma, melanoma lymphoma and myeloid leukemia cell lines (10-12). Thus, Ganoderma lucidum could be used as a potential therapeutic agent in the form of a dietary supplement for cancer patients.Epithelial ovarian cancer (EOC) is the most common form of ovarian cancer and the leading cause of death from gynecological disorders (13). The high mortality rate of EOC is mainly due to the late diagnosis and the lack of effective treatments for the late stages of the disease (14). The most effective treatment for EOC is surgery plus platinum-based chemotherapy, with drugs such as cisplatin. However, the majority of patients ultimately experience chemoresistance and recurrence of their disease (15). Considering the high mortality rate of ovarian cancer due to the absence of effective treatment in advanced stages or during relapse, new therapeutic strategies are urgently required.In this study, we examined the effects of Ganoderma lucidum on cell proliferation and migration in several ovarian cancer cell lines. Our results show that Ganoderma lucidum inhibits cell growth, migration and...

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“…A significant decrease in plasma glucose, phosphoenolpyruvate carboxykinase expression, and the body weight of rats have been reported. 15 PsP has also been reported 15 to have scavenger activity against free radicals, although it is 100 times less potent than ascorbic acid (vitamin C).…”

Section: Discussionmentioning

confidence: 99%

Reduction of histopathological images through a decrease in H2O2 levels in diabetic rats with polysaccharide peptides

Heriansyah

Wihastuti

Sargowo

et al. 2015

Biomarkers and Genomic Medicine

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Atherosclerosis occurs as a result of the oxidation of low-density lipoprotein (LDL) deposits, which later form plaques. Hyperglycemia, which occurs in patients with type 2 diabetes mellitus, is a risk factor for this kind of vascular damage. Oxidative stress from hydrogen peroxide (H 2 O 2 ) is increased in patients with hyperglycemia and therefore an antioxidant agent is required to prevent the destruction of the walls of blood vessels. This study aimed to show that Ganoderma lucidum polysaccharide peptide (PsP) can decrease the formation of H 2 O 2 . The study was an experimental in vivo post-test with control group design. Thirty-five Wistar rats (Rattus norwegicus) were divided into five groups (a normal diet group, a hypercholesterol diet group, and hypercholesterol groups that received doses of 50 mg/kg, 150 mg/kg, and 300 mg/kg body weight PsP). The parameters determined in this study were the level of H 2 O 2 , the lipid profile, insulin resistance, and the amounts of perivascular adipocyte tissue (PVAT), foam cells, and plaques. Each treatment group showed significant results for the administration of PsP using the one-way analysis of variance test (p < 0.050) for the reduction of H 2 O 2 (p Z 0.003), the lipid profile (cholesterol total and triglyceride; p Z 0.010, p Z 0.001), insulin resistance (p Z 0.003), the amount of PVAT (p <0.001), and plaques (p <0.001). The decrease in foam cells was insignificant (p Z 0.149), although an obvious pattern of reduction as a result of PsP treatment was observed. PsP from G. lucidum is a potent antioxidant and may * Corresponding author. Zainoel Abidin Hospital, Teuku Daoed Beureuh 108, Biomarkers and Genomic Medicine (2015) 7, 31e37 prevent the pathophysiology of atherosclerosis in patients with type 2 diabetes mellitus. The optimum dose in patients with type 2 diabetes mellitus is 300 mg/kg body weight. Further studies are required to determine the antioxidant effects of G. lucidum PsP and its benefits in the management of type 2 diabetes mellitus.

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Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice

Cited by 108 publications

References 20 publications

Attenuating effects of Ganoderma lucidum polysaccharides on myocardial collagen cross-linking relates to advanced glycation end product and antioxidant enzymes in high-fat-diet and streptozotocin-induced diabetic rats

Attenuating effects of Ganoderma lucidum polysaccharides on myocardial collagen cross-linking relates to advanced glycation end product and antioxidant enzymes in high-fat-diet and streptozotocin-induced diabetic rats

Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin

Reduction of histopathological images through a decrease in H2O2 levels in diabetic rats with polysaccharide peptides

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