2022
DOI: 10.1016/j.ejmech.2022.114422
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Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation

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Cited by 22 publications
(9 citation statements)
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“…The p53-deficient HCT-116 p53 (−/−) colon cancer cells were donated by a Collection of the Institute for Cancer Research at Vienna Medical University (Vienna, Austria). Cells were maintained in Dulbecco’s Modified Eagle Medium (DMEM, Biowest, France) or RPMI-1640 medium (Biowest, France), containing 10% of fetal bovine serum (FBS, Biowest, France) according to recommendations of American Type Culture Collection (ATCC), under the incubation conditions of 5% CO 2 humidity at 37 °C [ 53 ].…”
Section: Methodsmentioning
confidence: 99%
“…The p53-deficient HCT-116 p53 (−/−) colon cancer cells were donated by a Collection of the Institute for Cancer Research at Vienna Medical University (Vienna, Austria). Cells were maintained in Dulbecco’s Modified Eagle Medium (DMEM, Biowest, France) or RPMI-1640 medium (Biowest, France), containing 10% of fetal bovine serum (FBS, Biowest, France) according to recommendations of American Type Culture Collection (ATCC), under the incubation conditions of 5% CO 2 humidity at 37 °C [ 53 ].…”
Section: Methodsmentioning
confidence: 99%
“…A spectroscopic DNA interaction study was performed as previously described [ 63 ]. salmon sperm DNA (Sigma-Aldrich, USA) was diluted in Milli-Q water at 4 °C for 24 h at 1.65 mg/mL.…”
Section: Methodsmentioning
confidence: 99%
“…The diversity-oriented approach was applied for the synthesis of ciminalum-4-thiazolidinone hybrid molecules, and a series of derivatives were reported by Buzun and Finiuk [ 24 , 25 , 26 ]. For such a hybrid type, SAR analysis revealed that the presence of carboxylic acids [ 25 ], p-hydroxyphenyl [ 24 ], or (4-hydroxyphenyl)-pyrrolidine-2,5-dione [ 26 ] substituents at position 3 of the 4-thiazolidinone ring determines the most effective anti-tumor activity, while the absence of a substituent or presence of an additional ciminalum substituent at position 3 leads to a weakening in activity. Among the synthesized and screened hybrids, derivative 11 ( Figure 6 ) was cytotoxic toward MCF-7 and MDA-MB-231 breast cancer cell lines, with IC 50 values of 5.02 µM and 15.24 µM, respectively [ 25 ].…”
Section: Approved Drug–4-thiazolidinones Hybridsmentioning
confidence: 99%
“…Finiuk et al [ 26 ] reported on ciminalum–4-thiazolidinone hybrids containing phenyl-pyrrolidine-2,5-dione moieties in the molecules. The hit-compounds 14 and 15 ( Figure 6 ), possessing micromolar cytotoxic activity towards leukemia, colon cancer, CNS, and ovarian cancer cell lines, were identified following a 60 lines NCI protocol with total MG_MID GI 50 values of 1.76 and 1.73 μM, respectively.…”
Section: Approved Drug–4-thiazolidinones Hybridsmentioning
confidence: 99%