Novel Hybrid Morpholino-Glycopeptides with the Amino Acid Nitrogen Replacing C-3 of the Pyranose Ring

Chemical Modifications of Douglas Fir Bark, a Lignocellulosic By‐product—Enhancement of Their Lead(II) Binding Capacities

“…The biosorption experiments were carried out in batch conditions by adding 100 mg of crude or derivatized barks to 10 21 for stilbene derivative-grafted bark). The initial pH of each metal solution was adjusted to 5.0 with HNO 3 .…”

“…If this procedure is well documented in the case of purified polysaccharides, such as glycopyranosides, [21] cellulose, [22 -24] or hemicellulose from the xylan family [25] as described in one of our previous paper, however, to our knowledge, no reference exists regarding the direct chemical modifications of barks in aqueous media. If this procedure is well documented in the case of purified polysaccharides, such as glycopyranosides, [21] cellulose, [22 -24] or hemicellulose from the xylan family [25] as described in one of our previous paper, however, to our knowledge, no reference exists regarding the direct chemical modifications of barks in aqueous media.…”

“…4. The aldehyde functionalization is clearly identified through the variation of Unfortunately, the characteristic NH 2 absorption bands at 3300 -3500 cm 21 is not observed because of the overlap with the large OH band at 3200 -3600 cm 21 . The aldehyde functionalization is clearly identified through the variation of Unfortunately, the characteristic NH 2 absorption bands at 3300 -3500 cm 21 is not observed because of the overlap with the large OH band at 3200 -3600 cm 21 .…”

Glycosamino Acids: Building Blocks for Combinatorial Synthesis—Implications for Drug Discovery

“…[166] tion of the octylglucoside 185 affords dialdehyde 186, which can be purified easily by simple adsorption onto reverse-phase C-18 resins. Synthesis of morpholine-based GAAs.…”

Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside

“…To this aim, by treating 4 with NaIO 4 or Pb(OAc) 4 , we were able to carry out a double oxidative cleavage event on the sugar to provide dialdehyde 8 (Scheme 3), which served as a versatile intermediate. 38,39 Reduction of dialdehyde 8 with NaBH 4 provided tetrol substrate 9, which possessed good pharmacology but did not offer any advantages over 4 from a physicochemical properties standpoint. Dual reductive amination with dimethylamine provided the diamine 10, which, although lowering the tPSA, also realized a diminution in potency.…”