Novel hybrid liposomal formulations based on imidazolium-containing amphiphiles for drug encapsulation

Kuznetsova, Darya A.; Gabdrakhmanov, Dinar R.; Лукашенко, С. С.; Ahtamyanova, Landysh R.; Nizameev, Irek R.; Kadirov, Marsil K.; Zakharova, L. Ya.

doi:10.1016/j.colsurfb.2019.03.025

Cited by 26 publications

(14 citation statements)

References 25 publications

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“…Liposome preparation was carried out by the thin lipid hydration technique as follows [49][50][51]: a specific amount of DPPC (5.4 mg) was solved in 100 µL of chloroform. The solvent was removed by evaporation overnight at room temperature.…”

Section: Preparation Of Samplesmentioning

confidence: 99%

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

et al. 2021

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The solution behavior and physicochemical characteristics of polymer–colloid complexes based on cationic imidazolium amphiphile with a dodecyl tail (IA-12) and polyacrylic acid (PAA) or DNA decamer (oligonucleotide) were evaluated using tensiometry, conductometry, dynamic and electrophoretic light scattering and fluorescent spectroscopy and microscopy. It has been established that PAA addition to the surfactant system resulted in a ca. 200-fold decrease in the aggregation threshold of IA-12, with the hydrodynamic diameter of complexes ranging within 100–150 nm. Electrostatic forces are assumed to be the main driving force in the formation of IA-12/PAA complexes. Factors influencing the efficacy of the complexation of IA-12 with oligonucleotide were determined. The nonconventional mode of binding with the involvement of hydrophobic interactions and the intercalation mechanism is probably responsible for the IA-12/oligonucleotide complexation, and a minor contribution of electrostatic forces occurred. The latter was supported by zeta potential measurements and the gel electrophoresis technique, which demonstrated the low degree of charge neutralization of the complexes. Importantly, cellular uptake of the IA-12/oligonucleotide complex was confirmed by fluorescence microscopy and flow cytometry data on the example of M-HeLa cells. While single IA-12 samples exhibit roughly similar cytotoxicity, IA-12–oligonucleotide complexes show a selective effect toward M-HeLa cells (IC50 1.1 µM) compared to Chang liver cells (IC50 23.1 µM).

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Section: Preparation Of Samplesmentioning

confidence: 99%

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

et al. 2021

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“…Research activity of our group focuses on self-assembling amphiphilic systems, with their design, aggregation ability and functionality as drug delivery systems emphasized [2,37,38]. Recently, much attention has been paid to non-covalent modification of liposomes with surfactants [37][38][39][40], with cationic liposomes attracting special interest [41][42][43][44][45][46][47]. Main types of lipid-and silicon-containing nanoparticles, comprising many kinds of nanocarriers that can be used to achieve the best medical performance.…”

Section: Lipid Nanocarriers Modified With Amphiphilic Moleculesmentioning

confidence: 99%

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.

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“…As illustrated above, amphiphilic systems are of particular interest in biomedical applications [ 2 ], which can be supported by their use as hydrotropic additives [ 129 ], nanocontainers for poorly soluble drugs [ 130 , 131 , 132 , 133 ], antimicrobial preparations [ 134 , 135 ], complexing agents for negatively charged biomolecules such as DNA and BSA [ 136 , 137 , 138 , 139 , 140 ], etc. They have been successfully used for the fabrication of drug and gene delivery systems demonstrating numerous advantages compared to non-formulated drugs, i.e., improved bioavailability, higher stability and prolonged circulation in bioenvironment, lower side effects, etc.…”

Section: Self-assembled Amphiphilic Systems As Smart Drug Nanocarrmentioning

confidence: 99%

“…Cationic liposomes based on 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and alkyltriphenylphosphonium bromides were obtained by non-covalent surface modification with amphiphiles using varying hydrocarbon tail lengths and lipid/surfactant ratio and showed a high degree of colocalization with mitochondria of human pancreatic cancer cell line (PANC-1) [ 222 ]. Hybrid liposomes based on DPPC and 1-methyl-3-alkylimidazolium bromides have been used for metronidazole encapsulation [ 131 ]. It was shown that the highest value of encapsulation efficiency, equal to 75%, is achieved in the case of surface modification with an octadecyl derivative.…”

Section: Self-assembled Amphiphilic Systems As Smart Drug Nanocarrmentioning

confidence: 99%

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Kashapov

Gaynanova

Gabdrakhmanov

et al. 2020

IJMS

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This review focuses on synthetic and natural amphiphilic systems prepared from straight-chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale aggregates of different morphology and their application as drug carriers. Since numerous biological species (lipid membrane, bacterial cell wall, mucous membrane, corneal epithelium, biopolymers, e.g., proteins, nucleic acids) bear negatively charged fragments, much attention is paid to cationic carriers providing high affinity for encapsulated drugs to targeted cells. First part of the review is devoted to self-assembling and functional properties of surfactant systems, with special attention focusing on cationic amphiphiles, including those bearing natural or cleavable fragments. Further, lipid formulations, especially liposomes, are discussed in terms of their fabrication and application for intracellular drug delivery. This section highlights several features of these carriers, including noncovalent modification of lipid formulations by cationic surfactants, pH-responsive properties, endosomal escape, etc. Third part of the review deals with nanocarriers based on macrocyclic compounds, with such important characteristics as mucoadhesive properties emphasized. In this section, different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.

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Novel hybrid liposomal formulations based on imidazolium-containing amphiphiles for drug encapsulation

Cited by 26 publications

References 25 publications

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

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