Novel human astrovirus strains showing multiple recombinations within highly conserved ORF1b detected from hospitalized acute watery diarrhea cases in Kolkata, India

Pativada, Madhusudhan; Bhattacharya, R.K.; Krishnan, Triveni

doi:10.1016/j.meegid.2013.09.017

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…Recombinations between different animal AstVs have also been described (152,155,162,183). Although most recombination breakpoints have been identified upstream of the conserved ORF1b/ORF2 junction region (155,168,172,182), they are also frequent within ORF2 (152,155,172,177), and they may also exist within ORF1a (155,181) and ORF1b (155,177,180).…”

Section: Figmentioning

confidence: 99%

Human Astroviruses

2014

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SUMMARY Human astroviruses (HAtVs) are positive-sense single-stranded RNA viruses that were discovered in 1975. Astroviruses infecting other species, particularly mammalian and avian, were identified and classified into the genera Mamastrovirus and Avastrovirus . Through next-generation sequencing, many new astroviruses infecting different species, including humans, have been described, and the Astroviridae family shows a high diversity and zoonotic potential. Three divergent groups of HAstVs are recognized: the classic ( MAstV 1 ), HAstV-MLB ( MAstV 6 ), and HAstV-VA/HMO ( MAstV 8 and MAstV 9 ) groups. Classic HAstVs contain 8 serotypes and account for 2 to 9% of all acute nonbacterial gastroenteritis in children worldwide. Infections are usually self-limiting but can also spread systemically and cause severe infections in immunocompromised patients. The other groups have also been identified in children with gastroenteritis, but extraintestinal pathologies have been suggested for them as well. Classic HAstVs may be grown in cells, allowing the study of their cell cycle, which is similar to that of caliciviruses. The continuous emergence of new astroviruses with a potential zoonotic transmission highlights the need to gain insights on their biology in order to prevent future health threats. This review focuses on the basic virology, pathogenesis, host response, epidemiology, diagnostic assays, and prevention strategies for HAstVs.

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Section: Figmentioning

confidence: 99%

Human Astroviruses

2014

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“…; Pativada et al . ). In this study, the amplicon mapped at the conserved ORF1b/ORF2 junction, which was the main region undergoing recombination in HAstVs genome (Martella et al .…”

Section: Discussionmentioning

confidence: 97%

Molecular characterization of classic human astrovirus in eastern China, as revealed by environmental sewage surveillance

et al. 2016

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“…The ORF1b-ORF2 junction of the AstV genome is a hot spot at which recombination events frequently occur ( 6 , 8 , 9 , 27 , 28 ). In addition, recombination within the ORF1a gene has been reported ( 7 , 15 ).…”

Section: Discussionmentioning

confidence: 99%