Novel hollow biodegradable microneedle for amphotericin B delivery

Machekposhti, Sina Azizi; Kadian, Sachin; Vanderwal, Lyndsi; Stafslien, Shane J.; Narayan, Roger J.

doi:10.1002/mco2.321

Cited by 6 publications

(1 citation statement)

References 8 publications

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“…Finite element analysis (FEA) software, has been used to simulate and evaluate many applications and characteristics of HMNs, such as drug delivery and diffusion into the skin [52], UV light propagation for sensing and theranostics [53], mechanical and stress analysis [24,[54][55][56], insertion [54,55], and failure [24,54,57]. Henriquez et al performed indentation simulations to find a critical application load to avoid a structural failure during microneedle insertion into human skin for stainless steel and PLGA HMNs [54], with Faraji Rad et al using simulation to investigate the deflection of HMNs and stress distribution under a lateral bending force [24].…”

Section: Introductionmentioning

confidence: 99%

An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles

Defelippi,

Kwong,

Appleget

et al. 2024

Applied Mechanics

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A variety of hollow microneedle (HMN) designs has emerged for minimally invasive therapies and monitoring systems. In this study, a design change limiting the indentation depth of the (3D) printed custom microneedle assembly (circular array of five conical frusta with and without a stopper, aspect ratio = 1.875) fabricated using stereolithography has been experimentally validated and modeled in silico. The micro-indentation profiles generated in confined compression on 1 mm ± 0.073 mm alginate films enabled the generation of a Prony series, where displacement ranged from 100 to 250 µm. These constants were used as intrinsic properties simulating experimental ramp/release profiles. Puncture occurred on two distinct hydrogel formulations at the design depth of 150 µm and indentation rate of 0.1 mm/s characterized by a peak force of 3.5 N (H = 31 kPa) and 8.3 N (H = 36.5 kPa), respectively. Experimental and theoretical alignments for peak force trends were obtained when the printing resolution was simulated. Higher puncture force and uniformity inferred by the stopper was confirmed via microscopy and profilometry. Meanwhile, poroviscoelasticity characterization is required to distinguish mass loss vs. redistribution post-indentation through pycnometry. Results from this paper highlight the feasibility of insertion-depth control within the epidermis thickness for the first time in solid HMN literature.

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