Novel, Highly Sensitive, and Specific Assay to Monitor Acute Myocardial Infarction (AMI) by the Determination of Cardiac Troponin I (cTnI) and Heart-Type Fatty Acid Binding Protein (H-FABP) by a Colloidal Gold-Based Immunochromatographic Test Strip

Xin, Yuanrong; Yang, Renlong; Yang, Qing; Liu, Hongfei; Feng, Yingshu; Liu, Lin; Shi, Wenjing; Liu, Qiang

doi:10.1080/00032719.2020.1802594

Cited by 9 publications

(3 citation statements)

References 53 publications

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“…Recently, nanotechnology-based multimodel or multi-target and point-of-care testing (POCT) assays have emerged for detecting CAD biomarkers, helping to assess the disease process more accurately, rapidly, and conveniently. 18 , 24 , 25 , 28 , 44 , 46 , 47 , 48 , 49 , 50 , 51 , 52 Previous studies found that ratiometric ECL could eliminate environmental interference and allow precise measurement. Yang's group prepared AuNP-modified graphitic phase carbon nitride nanosheets (Au-CNNs) that acted as donors, which matched well with the adsorption of acceptor GPRu-Au (AuNP-loaded graphene oxide/polyethylenimine) and ultimately showed high stability and a low LOD ( Figure 1 D).…”

Section: Nanotechnology Approaches To Detect Cadsmentioning

confidence: 99%

Nanotechnology for cardiovascular diseases

Fang

et al. 2022

The Innovation

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Section: Nanotechnology Approaches To Detect Cadsmentioning

confidence: 99%

Nanotechnology for cardiovascular diseases

Fang

et al. 2022

The Innovation

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“…In addition, it has low cost, short detection time, intuitive detection results, and can be detected on-site (19). At present, GICT is widely used in many fields such as food (20)(21)(22), clinical medicine (23,24), environmental analysis (25,26), and biology (27). However, in the application of rapid detection in food, trace substances to be detected usually exist in complex food matrices, which pose great challenges to traditional CG-ICA in terms of sensitivity and matrix tolerance (28).…”

Section: Introductionmentioning

confidence: 99%

Development of a highly sensitive colloidal gold semiquantitative method for the determination of difenoconazole residues in citrus

Wang,

Gong,

Liu

et al. 2024

Front. Nutr.

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IntroductionDifenoconazole (DIFE) is a common pesticide used in citrus cultivation; excessive intake can cause neurological damage to the organism, and the existing colloidal gold immunochromatographic test strips cannot meet the requirements for the detection of citrus samples.MethodsDifenoconazole test strip was prepared based on the colloidal gold immunochromatographic technique (GICT), and its application in citrus samples was investigated; with colloidal gold (CG) as the probe, the optimization of GICT parameters, and the determination of reaction method, the immunochromatographic test strips for the detection of DIFE in citrus was developed, and the limit of detection (LOD), specificity, accuracy, and stability of the test strips were verified.ResultsThe results showed that the visual detection limit of the prepared colloidal gold immunochromatographic test strips was 0.2 mg/kg and the quantitative range was 0.06–0.6 mg/kg, and the test strips could specifically identify DIFE and have no cross-reaction with other common triazole pesticides. The detection method established in this study was verified by the GC–MS method, and the detection results achieved good consistency (R2 > 0.98).ConclusionThe test strips developed in this study have good performance and can be used for highly sensitive detection of citrus samples.

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“…"Cardiac troponin I (cTnI) is a myofibrilliar structural protein in myocardial cells used as a highly specific and sensitive serum biomarker for diagnosis of acute myocardial infarction" [14,15]. " However, it has been shown that other conditions including cardiac amyloidosis, pheochromocytoma, carcinoid syndrome, and massive pulmonary emboli can be presented with elevated serum level of cTnI" [14,15]. "Although there are several controversial studies about serum level of cTnI after CSE" [16].…”

Section: Introductionmentioning

confidence: 99%

Cardiac Troponin (cTnI) Level and Myocardial Functions in Children with Idiopathic Convulsive Status Epilepticus

Megahed,

Aziz,

El-Serogy

et al. 2023

JAMMR

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Background: A Seizure represents the clinical expression of abnormal, excessive, synchronous discharges of neurons residing primarily in the cerebral cortex. The aim of this study is to evaluate the myocardial functions and serum cardiac troponin (cTn-I) in children with convulsive status epilepticus without evidence of previous cerebrovascular diseases. Methods: This study was a case control study which was carried out in the duration of 1 year from December 2021 to December 2022 in Tanta University Hospital, Pediatric Department, Intensive care unit (ICU) and the emergency room. The diagnosis of status epilepticus had been made in accordance with the criteria of the International League against Epilepsy clinically as a generalized seizure (epileptic seizure with duration more than 5 minutes or recurrent again without regaining consciousness in between seizures). Another thirty (30) healthy children (16 males, 14 female) with age range from (3-15) years, with the mean age was (6.367±3.449) years, with no history of epilepsy or family history of neurological diseases, were enrolled in this study and were served as control group. Inclusion criteria were no sex predilection, Patients with age of (3-15) years, and children with convulsive status epilepticus. Convulsion type with duration more than 5 minutes or recurrent again without regaining consciousness in between seizures. Results: There was significant increase in serum level of cardiac troponin cTn-I among children with idiopathic convulsive status epilepticus than healthy Control children, (P <0.001*). All patients with elevated serum levels cTn-I had documented ECG changes. The test result had a high positive predictive value which indicates high specificity of the of mean serum level of cardiac troponin test and that, Children have high probability of having myocardial ischemia and injury following attacks of idiopathic convulsive status epilepticus. Conclusions: Convulsive status epilepticus triggers severe physical activities, while skeletal muscle contraction increases the cardiac afterload in the tonic stage, leading to a transient imbalance in the cardiac tissue demand, which is associated with myocardial cell damage. Neural-hormonal factors contribute to myocardial cell damage (e.g., prolonged seizure activity that occurs in status epilepticus).

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Novel, Highly Sensitive, and Specific Assay to Monitor Acute Myocardial Infarction (AMI) by the Determination of Cardiac Troponin I (cTnI) and Heart-Type Fatty Acid Binding Protein (H-FABP) by a Colloidal Gold-Based Immunochromatographic Test Strip

Cited by 9 publications

References 53 publications

Nanotechnology for cardiovascular diseases

Nanotechnology for cardiovascular diseases

Development of a highly sensitive colloidal gold semiquantitative method for the determination of difenoconazole residues in citrus

Cardiac Troponin (cTnI) Level and Myocardial Functions in Children with Idiopathic Convulsive Status Epilepticus

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