Novel high-loaded, nanoparticulate and thermally stable macromolecular prodrug design of NSAIDs based on hydroxypropylcellulose

Hussain, Muhammad Ajaz; Abbas, Khawar; Amin, Muhammad; Lodhi, Bilal Ahmed; Iqbal, Saima; Tahir, Muhammad Nawaz; Tremel, Wolfgang

doi:10.1007/s10570-014-0464-3

Cited by 16 publications

(15 citation statements)

References 29 publications

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“…Due to side effects and the high cost of nonsteroidal anti‐inflammatory drugs, there is an utmost need to develop cheaper and safer drugs from plants to treat inflammations (Gilani and Atta‐ur Rahman ; Hussain and others ). For this purpose, paw edema was induced by carrageenan in Wistar albino rats and mercury displacement technique was employed to study the anti‐inflammatory effect of ethanol extract of M. pudica leaves.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Mimosa pudica L., a High‐Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals

Muhammad

Hussain

Jantan³

et al. 2015

Comp Rev Food Sci Food Safe

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Mimosa pudica Linn. (Family: Mimosaceae) is used as an ornamental plant due to its thigmonastic and nyctinastic movements. M. pudica is also used to avoid or cure several disorders like cancer, diabetes, hepatitis, obesity, and urinary infections. M. pudica is famous for its anticancer alkaloid, mimosine, along with several valuable secondary metabolites like tannins, steroids, flavonoids, triterpenes, and glycosylflavones. A wide array of pharmacological properties like antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, antinociceptive, anticonvulsant, antidepressant, antidiarrheal, hypolipidemic activities, diuretic, antiparasitic, antimalarial, and hypoglycemic have been attributed to different parts of M. pudica. Glucuronoxylan polysaccharide extruded from seeds of M. pudica is used for drug release formulations due to its high swelling index. This review covers a thorough examination of functional bioactives as well as pharmacological and phytomedicinal attributes of the plant with the purpose of exploring its pharmaceutical and nutraceutical potentials.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Mimosa pudica L., a High‐Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals

Muhammad

Hussain

Jantan³

et al. 2015

Comp Rev Food Sci Food Safe

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“…Broido method and Flynn‐Wall‐Ozawa (FWO) method are two common methods that are used to deal with thermal Oxidation kinetics . In this work, as the thermo‐oxidative degradation kinetic curves of the samples were complicated because of the thermal barrier effect of MMT and the influence of air environment, FWO method was more suitable in this situation than Broido method.…”

Section: Resultsmentioning

confidence: 99%

Thermal stability and thermal oxidation kinetics of PU/CA‐MMT composites

Zhao

Hong

Shen

et al. 2018

J of Applied Polymer Sci

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In this work, we prepared three composites polyurethane (PU)/chlorhexidine acetate (CA), PU/montmorillonite (MMT), and PU/CA‐MMT, and investigated their kinetics of thermal degradation at different heating rates at atmosphere. These materials had good thermal stability and aging resistance. The thermal stability of PU/CA (Tonset: 237.3°C) was not obviously enhanced by the addition of only CA when compared with that of PU (Tonset: 232.3°C), while the thermal stability of PU/MMT (Tonset: 273.4°C) was considerably enhanced by the addition of MMT due to the high thermal stability of MMT. CA‐MMT filler was dispersed and exfoliated in PU more easily than CA or MMT in PU, so the composite PU/CA‐MMT possessed the best thermal stability (Tonset: 285.8°C). In addition, PU/CA‐MMT also had the best resistance to bacterial adhesion and antibacterial ability. The analysis with Flynn‐Wall‐Ozawa method showed that the activation energy of thermal oxidation of PU increased when CA‐MMT was added and thus its anti‐aging ability was enhanced, and the thermal oxidation of these four materials was first‐order reaction. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47002.

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“…Development of cheap, safe herbal medicine from herbacious plants for anti‐inflammatory treatment has become more and more of interest because of the side effects and high cost of non‐steroidal medicine (Hussain et al ., ). To evaluate anti‐inflammatory and antinociceptive activity, chemical, thermal‐induced pain and fresh egg albumin‐induced inflammation and pentylenetetrazol (PTZ)‐induced convulsion in rodents was applied to study the effects of methanolic extracts of A. pubescens roots.…”

Section: Pharmacological Activitiesmentioning

confidence: 97%

Phytochemical compounds and biological activity in Asparagus roots: a review

Zhang

Birch

Pei

et al. 2018

Int J of Food Sci Tech

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Asparagus roots (AR) contain many bioactive compounds and their use in Chinese and Indian traditional medicines is well documented. Both in vitro and in vivo studies have indicated AR extracts act as antidiabetic, antioxidant and hypolipidaemic and depict anti-inflammatory, antibacterial, antiviral, anticarcinogenic activities and also improve cardiovascular and oral health. The physiological effects against wide range of pathologies are due to the wide range of phytochemicals found in AR including polyphenols, saponins and polysaccharides. The aim of this review is to present an overview of the functional, medical and physiological properties of AR bioactives. This review considers the roots of several asparagus species and provides up-to-date information on Asparagus officinalis that has not been extensively reviewed before.

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Novel high-loaded, nanoparticulate and thermally stable macromolecular prodrug design of NSAIDs based on hydroxypropylcellulose

Cited by 16 publications

References 29 publications

Mimosa pudica L., a High‐Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals

Mimosa pudica L., a High‐Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals

Thermal stability and thermal oxidation kinetics of PU/CA‐MMT composites

Phytochemical compounds and biological activity in Asparagus roots: a review

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