Novel hGHRH homodimer promotes fertility of female infertile hamster by up-regulating ovarian GHRH receptor without triggering GH secretion

Zhang, Juan-Hui; Zhang, Xudong; Yue, Lin-Na; Guo, Xiaoyuan; Tang, Jing-Xuan; Guo, Lirong; Li, Yun; Tang, Song-Shan

doi:10.1016/j.ejps.2018.03.012

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…In fact, recently it has been reported that a GHRH homodimer up-regulates the ovarian GHRH receptor increasing the development and maturation of follicles without affecting ovarian GH production, at least in an animal model (114). Another important GH secretagogue, such as ghrelin, has been found to increase GH secretion, but not GH synthesis, in porcine follicles in vitro (115), and ghrelin and its receptor have been found in the ovaries of pig and hen (116, 117). However, administration of ghrelin does not induce ovarian GH release in cultured ovaries in chicken (118).…”

Section: Ovarian Angiogenesismentioning

confidence: 99%

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The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

Devesa¹,

Caicedo

2019

Front. Endocrinol.

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Although not yet well-understood, today it is clear that Growth Hormone (GH) exerts a relevant role in the regulation of ovulation and fertility; in fact, fertility is lower in women with GH deficiency (GHD), and GH receptors (GHR) and GH mRNA have been found in the ovary since the onset of follicular development in humans. However, despite the strong evidence of GH in the regulation of fertility, many aspects of GH actions at this level are still not well-established, and it is likely that some controversial data depend on the species analyzed, the dose of the hormone and the duration of use of GH. Folliculogenesis, ovulation, and corpus luteum formation and maintenance are processes that are critically dependent on angiogenesis. In the ovary, new blood vessel formation facilitates oxygen, nutrients, and hormone substrate delivery, and also secures transfer of different hormones to targeted cells. Some growth factors and hormones overlap their actions in order to control the angiogenic process for fertility. However, we still know very little about the factors that play a critical role in the vascular changes that occur during folliculogenesis or luteal regression. To promote and maintain the production of VEGF-A in granulosa cells, the effects of local factors such as IGF-I and steroids are needed; that VEGF-A-inducing effect cannot be induced by luteinizing hormone (LH) or chorionic gonadotropin (CG) alone. As a result of the influences that GH exerts on the hypothalamic-pituitary-gonadal axis, facilitating the release of gonadotropins, and given the relationship between GH and local ovarian factors such as VEGF-A, FGF-2, IGF-1, or production of sex steroids, we assume that GH has to be a necessary factor in ovarian angiogenesis, as it happens in other vascular beds. In this review we will discuss the actions of GH in the ovary, most of them likely due to the local production of the hormone and its mediators.

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Section: Ovarian Angiogenesismentioning

confidence: 99%

“…However, administration of ghrelin does not induce ovarian GH release in cultured ovaries in chicken (118). Paradoxically, ovarian GH stimulates ghrelin synthesis and secretion (115).…”

Section: Ovarian Angiogenesismentioning

confidence: 99%

The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

Devesa¹,

Caicedo

2019

Front. Endocrinol.

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“…GHRH significantly stimulates progesterone production and cAMP accumulation in rat ovarian granulosa cells in a dose-dependent manner. GHRH has an effect on ovarian steroid production in rats and is involved in the regulation of the key steroid production steps related to progesterone degradation (Zhang et al 2018). Most GH cells have GHRH receptors, indicating that GHRH is partially involved in the regulation of growth hormone (GH).…”

Section: Discussionmentioning

confidence: 99%

Expression of microRNAs in the hypothalamus of pregnant and non-pregnant goats

Zhu¹,

Huang²,

Jing³

et al. 2021

CZECH J ANIM SCI

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MicroRNAs (miRNAs) play a significant role in animal reproduction by regulating the expression of protein-coding genes. The hypothalamus regulates the pregnancy cycle changes in goats; however, the action mechanism of miRNAs in this regulation remains to be investigated. In this study, we performed RNA sequencing of hypothalamus samples to establish a comprehensive miRNA profiling of pregnant and non-pregnant goats. A total of 384 miRNAs were identified in the hypothalamus of pregnant goats, of which 239 were newly discovered, and 390 miRNAs were detected in the hypothalamus of non-pregnant goats of which 192 were novel miRNAs. In addition, a total of 280 differentially expressed miRNAs are characterized, of which 171 were known miRNAs and 109 were novel miRNAs. Functional enrichment suggests that the predicted target genes of differentially expressed miRNAs may be involved in the reproductive process. This preliminary study revealed that let-7f-5p, miR-99a-5p and miR-100-5p may be involved in the hypothalamic regulation of pregnancy cycle changes in goats. These data provide a basic reference for subsequent studies on the regulatory role of miRNAs in mammalian pregnancy.

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The allostery and modification of hGHRH molecules and specific dimer produced significant fertility effect by proliferating and activating in-situ ovarian mesenchymal stem cells

Zhang,

Luo,

et al. 2024

European Journal of Pharmaceutical Sciences

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Novel hGHRH homodimer promotes fertility of female infertile hamster by up-regulating ovarian GHRH receptor without triggering GH secretion

Cited by 3 publications

References 19 publications

The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

The Role of Growth Hormone on Ovarian Functioning and Ovarian Angiogenesis

Expression of microRNAs in the hypothalamus of pregnant and non-pregnant goats

The allostery and modification of hGHRH molecules and specific dimer produced significant fertility effect by proliferating and activating in-situ ovarian mesenchymal stem cells

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