Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages

Wu, Jiang; Chen, Anqi; Zhou, Yajiao; Zheng, Sen; Yang, Yintang; An, Yu; Xu, Ke; He, Huacheng; Kang, Jianming; Luckanagul, Jittima Amie; Xian, Ming; Xiao, Jian; Wang, Qian

doi:10.1016/j.biomaterials.2019.119398

Cited by 151 publications

(118 citation statements)

References 68 publications

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“…Therefore, we next examined whether PUN has a direct inhibitory effect on inflammation. Previous studies have demonstrated that macrophages undergo morphological alterations after stimulation with different molecular signals (McWhorter et al, 2013;Wu et al, 2019). Figure 6A illustrates that macrophages appeared round and had a clustered morphology in the absence of LPS and PUN.…”

Section: Pun Inhibited the Macrophage Proinflammatory Phenotype And Pmentioning

confidence: 85%

Protective Effects of Punicalagin on Osteoporosis by Inhibiting Osteoclastogenesis and Inflammation via the NF-κB and MAPK Pathways

et al. 2020

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Postmenopausal osteoporosis is a worldwide disease characterized by reduced bone mineral density and increased fracture risk. Inflammatory bone loss due to excessive osteoclast bone resorption is significant in the pathogenesis and development of osteoporosis. Punicalagin (PUN) is a pomegranate fruit derivative and has potential antiinflammatory effects. However, the effect of PUN on osteoporotic bone loss has yet to be clarified. In this study, we investigated the effect of PUN on RANKL-induced osteoclast formation and bone resorption in vitro, as well as its potential therapeutic effect on ovariectomized-induced bone loss in vivo. PUN was demonstrated to suppress osteoclast formation and bone resorptive function dose-dependently, while osteoclastspecific genes were also downregulated by PUN. In vivo micro-CT and histopathological staining showed that the OVX procedure led to significant bone loss characterized by decreased bone parameters and increased osteoclast numbers, while PUN treatment dramatically prevented these changes. Furthermore, PUN treatment effectively inhibited proinflammatory cytokine expression in vitro. Mechanistically, PUN maintained bone mass via suppressing nuclear factor kB (NF-kB) and mitogen-activated protein kinase (MAPK) signaling pathway activation. Collectively, our observations provide evidence that PUN is a potential candidate for the treatment of osteoporosis.

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Section: Pun Inhibited the Macrophage Proinflammatory Phenotype And Pmentioning

confidence: 85%

Protective Effects of Punicalagin on Osteoporosis by Inhibiting Osteoclastogenesis and Inflammation via the NF-κB and MAPK Pathways

et al. 2020

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“…Replenishment of H 2 S inhibits macrophage activation and improves wound healing in both oral mucosal wound model and diabetic wound model 46,67 . In situ induction of M2 macrophages by employing the novel H 2 S‐releasing hydrogel greatly improves wound healing process, which displays a promising translational potential 68 . Together, these results support that targeting H 2 S signalling in macrophages could be a viable approach to fight against immune and metabolic disorders in clinical settings and to restore tissue homeostasis upon trauma.…”

Section: The Therapeutic Potential For Targeting H2s Signalling In Mamentioning

confidence: 99%

The role of hydrogen sulphide signalling in macrophage activation

et al. 2020

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“…Wound healing is a highly ordered biological process, encompassing three programmed but overlapping phases including hemostasis and inflammation, proliferation, and remodeling. [ 10 ] Upon injury, several types of cell strains will be immediately recruited and mobilized, promoting skin regeneration, and maintaining its integrity and function. [ 11 ] Specifically, macrophages play a central role in regulating inflammation and strongly influence the skin repair process, which can be polarized into classically M1 type (inflammatory phenotype in early stage) and M2 type (anti‐inflammatory phenotype in the mid‐stage).…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Nanofibrous Glycopeptide Hydrogel Dressing for Accelerating Wound Healing: A Cytokine‐Free, M2‐Type Macrophage Polarization Approach

Feng

Zhang

et al. 2020

Adv Funct Materials

148

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Wound management remains a major concern in clinical care. Conventional dressings and hydrogels delivering drugs or cells can drive wound healing. However, these approaches are limited either by unnecessary bleeding and tissue tearing, or sophisticated fabrication, high cost, and drug-related side effects. Herein, a novel bioinspired glycopeptide hydrogel is rationally designed to mimic the glycoprotein components and nanofibrous architecture of cutaneous extracellular matrix (ECM) for self-accelerating the wound healing by regulating macrophage polarization without any additional therapeutic agents. The glycopeptide hydrogel, termed as GM-peptide hybrid hydrogel (GP gel), is established by the self-assembly of β-sheet Q11 peptide-grafted glucomannan, with nanofibrous structure, high water content, porosity, and self-healing properties. It is observed that GP gel displays remarkable capability of polarizing primary macrophages to M2-type phenotype in vitro and in vivo by inducing the activation of mannose receptors through ERK/STAT6 pathway. GP gel unprecedentedly expedites the wound closure rate and the regeneration of epidermis tissues in full-thickness skin excision models without drugs, exogenous cytokines, or seeded cells. More significantly, GP gel could promote angiogenesis in the repaired skin tissues. Collectively, such a novel ECM-mimicking glycopeptide hydrogel provides a highly effective treatment approach for skin wounds and may serve as a promising scaffold in regenerative medicine.

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Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages

Cited by 151 publications

References 68 publications

Protective Effects of Punicalagin on Osteoporosis by Inhibiting Osteoclastogenesis and Inflammation via the NF-κB and MAPK Pathways

Protective Effects of Punicalagin on Osteoporosis by Inhibiting Osteoclastogenesis and Inflammation via the NF-κB and MAPK Pathways

The role of hydrogen sulphide signalling in macrophage activation

Bioinspired Nanofibrous Glycopeptide Hydrogel Dressing for Accelerating Wound Healing: A Cytokine‐Free, M2‐Type Macrophage Polarization Approach

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