Novel H1N1 influenza in neonates: from mild to fatal disease

Martic, Jelena; Savić, Nataša; Minić, Predrag; Pašić, Srdjan; Nedeljković, Jasminka; Janković, Bojan

doi:10.1038/jp.2010.194

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…Our study is the first to demonstrate milder H1N1pdm clinical disease in young animals than their adult counterparts. Importantly, these clinical observations in our ferret animal model paralleled the clinical observations for humans from the 2009 H1N1 influenza virus pandemic which reported that children had milder clinical symptoms than adults (32,45,52,78,89,98,99). Further investigation of this age-related differential disease pathogenesis in our ferret model revealed that although both newly weaned and adult ferrets cleared the viral infection at a similar rate, the blood cell profiles differed markedly between the groups and the resulting lung pathology was more severe in the adults.…”

Section: Discussionsupporting

confidence: 79%

“…During the spring and fall 2009 pandemic waves in North America, pediatric patients accounted for at least 30% to 40% of the total H1N1pdm hospital admissions (32,78). Unexpectedly, recent clinical reports and case studies suggested that the clinical symptoms of the majority of H1N1pdm pediatric patients were mild to moderate (32,45,52,78,89,98,99). In addition, severe H1N1pdm cases (including those requiring admission to an intensive care unit and those involving fatalities) were more frequent in the older age groups.…”

mentioning

confidence: 99%

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Differential Pathological and Immune Responses in Newly Weaned Ferrets Are Associated with a Mild Clinical Outcome of Pandemic 2009 H1N1 Infection

Huang

Banner

Dégousée

et al. 2012

J Virol

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h Young children are typically considered a high-risk group for disease associated with influenza virus infection. Interestingly, recent clinical reports suggested that young children were the smallest group of cases with severe pandemic 2009 H1N1 (H1N1pdm) influenza virus infection. Here we established a newly weaned ferret model for the investigation of H1N1pdm infection in young age groups compared to adults. We found that young ferrets had a significantly milder fever and less weight loss than adult ferrets, which paralleled the mild clinical symptoms in the younger humans. Although there was no significant difference in viral clearance, disease severity was associated with pulmonary pathology, where newly weaned ferrets had an earlier pathology improvement. We examined the immune responses associated with protection of the young age group during H1N1pdm infection. We found that interferon and regulatory interleukin-10 responses were more robust in the lungs of young ferrets. In contrast, myeloperoxidase and major histocompatibility complex responses were persistently higher in the adult lungs; as well, the numbers of inflammation-prone granulocytes were highly elevated in the adult peripheral blood. Importantly, we observed that H1N1pdm infection triggered formation of lung structures that resembled inducible bronchus-associated lymphoid tissues (iBALTs) in young ferrets which were associated with high levels of homeostatic chemokines CCL19 and CXCL13, but these were not seen in the adult ferrets with severe disease. These results may be extrapolated to a model of the mild disease seen in human children. Furthermore, these mechanistic analyses provide significant new insight into the developing immune system and effective strategies for intervention and vaccination against respiratory viruses.

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Section: Discussionsupporting

confidence: 79%

mentioning

confidence: 99%

Differential Pathological and Immune Responses in Newly Weaned Ferrets Are Associated with a Mild Clinical Outcome of Pandemic 2009 H1N1 Infection

Huang

Banner

Dégousée

et al. 2012

J Virol

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“…Severe respiratory distress syndrome, which is observed in hyaline membrane disease, could be one presentation of a full-term infant with neonatal influenza, as in our case. A similar presentation has been reported by Martic et al [8] in full-term infants with influenza H1N1; however, to the best of our knowledge, no cases have been reported with influenza B. Serious brain injuries and convulsions have been reported, although these were not seen in our case [9].…”

Section: Discussionsupporting

confidence: 88%

Unusual Presentation of Influenza B Virus in a Neonate

Zahrani¹,

Hantash²,

Abdoun³

et al. 2020

DSAHMJ

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“…Although many hospitals struggled with the implementation of the CDC guidance during the pandemic related to balancing family‐centered care and support of breastfeeding while limiting the risk of infection transmission to well newborns (Gupta & Pursley, ), transmission to newborns via contact with infected respiratory droplets was a possibility, and cases of nosocomial infection in newborns during the pandemic were documented, including probable transmission by direct contact with ill family members or caregivers (Enstone et al., ; Fanella et al., ; Martic et al., ).…”

Section: Discussionmentioning

confidence: 99%

Postpartum and Neonatal Nursing Care During the 2009 H1N1 Influenza Pandemic

Zapata¹,

Ruch‐Ross²,

Williams³

et al. 2013

Nursing for Women's Health

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We describe select influenza infection control policies and practices related to postpartum and newborn care during the 2009 H1N1 pandemic. In an online survey of obstetric and neonatal nurses, significantly more nurses indicated a written hospital policy supporting each of the practices during versus before the pandemic. The two practices least oft en implemented were temporary separation of healthy newborns from ill mothers (37.7 percent) and testing newborns for influenza virus infection if signs of influenza were observed (31.4 percent). Presence of written hospital policies increased implementation of practices. Findings may be useful to guide planning for future pandemics or other public health emergencies.

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Novel H1N1 influenza in neonates: from mild to fatal disease

Cited by 12 publications

References 8 publications

Differential Pathological and Immune Responses in Newly Weaned Ferrets Are Associated with a Mild Clinical Outcome of Pandemic 2009 H1N1 Infection

Differential Pathological and Immune Responses in Newly Weaned Ferrets Are Associated with a Mild Clinical Outcome of Pandemic 2009 H1N1 Infection

Unusual Presentation of Influenza B Virus in a Neonate

Postpartum and Neonatal Nursing Care During the 2009 H1N1 Influenza Pandemic

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