Novel Gut Microbiota Patterns Involved in the Attenuation of Dextran Sodium Sulfate-Induced Mouse Colitis Mediated by Glycerol Monolaurate via Inducing Anti-inflammatory Responses

Abstract

The gut microbiota, which can be highly and dynamically affected by dietary components, is closely related to IBD pathogenesis. Here, we demonstrated that food-grade glycerol monolaurate (GML)-mediated enhancement of Bifidobacterium and fecal SCFAs could be responsible for the anticolitis effect.

Trans-anal irrigation in patients with multiple sclerosis: Efficacy in treating disease-related bowel dysfunctions and impact on the gut microbiota: A monocentric prospective study

“…Lachnospira , Coprococcus and Ruminococcus ) and even higher proportions of Actinomyces and Turicibacter . Although not much information is available on these microorganisms, Turicibacter has recently been identified as a potential gut inflammation-related taxon, 32 as well as a possible marker of the chronic-progressive form of MS, 33 and it is known that Actinomyces could aggravate lesions caused by inflammatory states by inducing changes in the enteric environment and modulating immune responses. 34 As expected, MS-related GM alteration was more severe in patients with progressive form, who were particularly enriched in Streptococcus and [ Ruminococcus ].…”

Dietary emulsifier glycerol monodecanoate affects the gut microbiota contributing to regulating lipid metabolism, insulin sensitivity and inflammation

“…48 Notably, Mo et al found that GML could attenuate mouse colitis through the enhancement of Bifidobacterium and fecal short-chain fatty acids (SCFAs). 9 Furthermore, it has also been reported that Bifidobacterium could strengthen the intestinal epithelial tight junction barrier and prevent intestinal inflammation. 49,50 Given that 1600 mg kg −1 GMD supplementation could also increase the Bifidobacterium abundance, we hypothesized that 1600 mg kg −1 GMD would improve the intestinal barrier function by increasing the Bifidobacterium abundance, which would then lead to a decrease in the serum levels of pro-inflammation cytokines.…”

“…6,7 The remarkable effects of GML in attenuating metabolic syndrome and inflammation have been verified. 8,9 However, although many studies have been conducted so far on the antibacterial effect of GMD in vitro, 1,10 the overall evaluation of the effects on the whole metabolism and host health is still scarce.…”

Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?

“…The protective effect of GML on colitis and the potential dysbiosis-related mechanism were also assessed [ 48 , 51 ]. GML pretreatment is superior to GML cotreatment for colitis.…”