Novel Glycopolymer Brushes via ATRP: 2. Thermal and Mechanical Properties

Fleet, Reda; Dungen, Eric T. A. van den; Klumperman, Bert

doi:10.1002/macp.201100289

Cited by 4 publications

(3 citation statements)

References 41 publications

(67 reference statements)

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“…Moreover, the elimination of absorbed water was detected at around 150 °C since the glycopolymers are very hygroscopic. A similar observation of water elimination was reported in the literature for other types of glycopolymers …”

Section: Resultssupporting

confidence: 88%

Green Synthesis of Glycopolymers Using an Enzymatic Approach

Adharis

Loos

2019

Macro Chemistry & Physics

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β‐Glucosidase and horseradish peroxidase (HRP) are used as biocatalysts in aqueous solution for the enzymatic synthesis of glycomonomers and the respective enzymatic polymerization toward glycopolymers. The biocatalytically synthesized monomers contain (meth)acrylate functionalities that are able to be polymerized by an enzyme‐initiated polymerization using an HRP/hydrogen peroxide/acetylacetone ternary system. The structure of the glycomonomers and the respective glycopolymers as well as the monomer conversion after the reaction are determined by 1H NMR spectroscopy. The synthesized glycopolymers have a dispersity and a number‐average molecular weight up to 5.8 and 297 kg mol−1, respectively. Thermal and degradation properties of the glycopolymers are studied by differential scanning calorimetry and thermogravimetric analysis. In addition, preparation of glycopolymers via conventional free radical polymerization is performed and the properties of the obtained polymers are compared with the enzymatically synthesized glycopolymers.

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Section: Resultssupporting

confidence: 88%

Green Synthesis of Glycopolymers Using an Enzymatic Approach

Adharis

Loos

2019

Macro Chemistry & Physics

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“…In most of the cases, this assumption could be very far from reality. N -methyl- d -glucamine and different glucose- and glucosamine-based acrylamide or (meth)acrylate monomers [ 30 , 33 , 43 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ], ( Figure 4 ), either in their linear or ring form, have been synthesized and used for the preparation of well-defined polymer brushes by RDRP methods. The resultant materials have been extensively studied mainly for the specific binding and recognition by lectins [ 22 , 24 , 25 , 38 , 39 , 41 , 48 , 49 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Glucose-containing Polymer Brushesmentioning

confidence: 99%

Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges

et al. 2020

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The cellular surface contains specific proteins, also known as lectins, that are carbohydrates receptors involved in different biological events, such as cell–cell adhesion, cell recognition and cell differentiation. The synthesis of well-defined polymers containing carbohydrate units, known as glycopolymers, by reversible deactivation radical polymerization (RDRP) methods allows the development of tailor-made materials with high affinity for lectins because of their multivalent interaction. These polymers are promising candidates for the biomedical field, namely as novel diagnostic disease markers, biosensors, or carriers for tumor-targeted therapy. Although linear glycopolymers are extensively studied for lectin recognition, branched glycopolymeric structures, such as polymer brushes can establish stronger interactions with lectins. This specific glycopolymer topology can be synthesized in a bottlebrush form or grafted to/from surfaces by using RDRP methods, allowing a precise control over molecular weight, grafting density, and brush thickness. Here, the preparation and application of glycopolymer brushes is critically discussed and future research directions on this topic are suggested.

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“…Klumperman et al [129,148,149] described the synthesis of a series of cylindrical brushes carrying α-methylglucoside-functionalized graft chains and investigated their thermal and mechanical properties (Entry 101-104, Table 2). To this end, four macroinitiators based on HEMA (M33), MMA (M15), 4-vinylbenzyl chloride (M58), and maleic anhydride (MAnh) were synthesized by ATRP or RAFT copolymerization, followed by chemical modification with 2-bromo-2-methylpropionyl bromide as needed.…”

Section: Scheme 13mentioning

confidence: 99%

Synthesis of Glycopolymer Architectures by Reversible-Deactivation Radical Polymerization

Ghadban

Albertin

2013

Polymers

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This review summarizes the state of the art in the synthesis of well-defined glycopolymers by Reversible-Deactivation Radical Polymerization (RDRP) from its inception in 1998 until August 2012. Glycopolymers architectures have been successfully synthesized with four major RDRP techniques: Nitroxide-mediated radical polymerization (NMP), cyanoxyl-mediated radical polymerization (CMRP), atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization. Over 140 publications were analyzed and their results summarized according to the technique used and the type of monomer(s) and carbohydrates involved. Particular emphasis was placed on the experimental conditions used, the structure obtained (comonomer distribution, topology), the degree of control achieved and the (potential) applications sought. A list of representative examples for each polymerization process can be found in tables placed at the beginning of each section covering a particular RDRP technique.

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Novel Glycopolymer Brushes via ATRP: 2. Thermal and Mechanical Properties

Cited by 4 publications

References 41 publications

Green Synthesis of Glycopolymers Using an Enzymatic Approach

Green Synthesis of Glycopolymers Using an Enzymatic Approach

Glycopolymer Brushes by Reversible Deactivation Radical Polymerization: Preparation, Applications, and Future Challenges

Synthesis of Glycopolymer Architectures by Reversible-Deactivation Radical Polymerization

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