2015
DOI: 10.1093/jac/dkv001
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Novel gentamicin resistance genes in Campylobacter isolated from humans and retail meats in the USA

Abstract: This study demonstrated that several new aminoglycoside resistance genes underlie the recent emergence of gentamicin-resistant Campylobacter, and that, in addition to contaminated retail chicken, other sources have also contributed to gentamicin-resistant Campylobacter infections in humans.

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Cited by 55 publications
(55 citation statements)
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“…We identified seven GEN r genes, but only aph(2Љ)-If and aph(2Љ)-Ig were shared in isolates recovered from humans, poultry, and poultry meats. Our recent study showed that the genetically diverse APH(2Љ) family was a major contributor to GEN r in Campylobacter, with amino acid identity between the subfamilies ranging from 26% to 52% (23). Using this new knowledge, we were able to successfully correlate resistance genotypes and phenotypes for the vast majority of isolates.…”
Section: Discussionmentioning
confidence: 97%
“…We identified seven GEN r genes, but only aph(2Љ)-If and aph(2Љ)-Ig were shared in isolates recovered from humans, poultry, and poultry meats. Our recent study showed that the genetically diverse APH(2Љ) family was a major contributor to GEN r in Campylobacter, with amino acid identity between the subfamilies ranging from 26% to 52% (23). Using this new knowledge, we were able to successfully correlate resistance genotypes and phenotypes for the vast majority of isolates.…”
Section: Discussionmentioning
confidence: 97%
“…An increase in gentamicin resistance in C. coli from retail chicken the USA has recently been observed (FDA, 2011), with most isolates originating from the western region of the USA and apparently related to the clonal expansion of a particular C. coli lineage. The resistance gene aph(2'')-Ig was responsible for conferring gentamicin resistance in these USA retail chicken C. coli isolates and was colocated on a plasmid which also carried tet(O) resistance (Zhao et al, 2015). Gentamicin resistance was detected in C. jejuni from broilers and turkeys, and C. coli from broilers in EU MSs in 2014, although whether clonal expansion of strains is also playing any role in the occurrence of gentamicin resistance in these Campylobacter isolates is not known.…”
Section: Antimicrobial Resistance In Campylobacter In Poultry and Meamentioning
confidence: 99%
“…In the United States, gentamicin resistance in Campylobacter was rarely reported before 2007 according to National Antimicrobial Resistance Monitoring System (NARMS) studies; however, an increasing trend of resis-tance to aminoglycosides was observed in recent years (9). In 2011, 12.2% of human isolates and 18.1% of retail isolates showed resistance to aminoglycosides (9). In China, the gentamicin resistance rate in Campylobacter has been at a much higher level than in other countries (10)(11)(12).…”
mentioning
confidence: 99%
“…The aacA/aphD gene encoding a bifunctional enzyme was associated with gentamicin resistance (16). Very recently, several variants of 2Љ-phosphotransferase accounting for gentamicin resistance were identified in Campylobacter in the United States (9,17).…”
mentioning
confidence: 99%