Novel genes and insights in complete asthma remission: A genome‐wide association study on clinical and complete asthma remission

Vonk, Judith M.; Nieuwenhuis, Maartje A.E.; Dijk, F. Nicole; Boudier, Anne; Siroux, Valérie; Probst‐Hensch, Nicole; Imboden, Medea; Keidel, Dirk; Sin, Don D.; Bossé, Yohan; Hao, Ke; Berge, Maarten van den; Faiz, Alen; Koppelman, Gerard H.; Postma, Dirkje S.

doi:10.1111/cea.13181

Cited by 19 publications

(23 citation statements)

References 37 publications

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“…Remission rates are higher in children with an asthma diagnosis than in adults with an asthma diagnosis. 54,55 Vonk et al 56 performed GWASs of clinical remission and complete remission of asthma in 178 and 55 subjects, respectively, after a median follow-up of 15.5 years among a cohort of 790 asthma cases. No locus in either GWAS was genome-wide significant, likely because of the small number of cases and limited power to detect associations.…”

Section: Gwass Of Asthma Remissionmentioning

confidence: 99%

Advances in asthma and allergic disease genetics: Is bigger always better?

Schoettler

Rodríguez

Weidinger

et al. 2019

Journal of Allergy and Clinical Immunology

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This review focuses on genome-wide association studies (GWASs) of asthma and allergic diseases published between January 1, 2018, and June 30, 2019. During this time period, there were 38 GWASs reported in 19 articles, including the largest performed to date for many of these conditions. Overall, we learned that childhood-onset asthma is associated with the most independent loci compared with other defined groups of asthma and allergic disease cases; adult-onset asthma and moderate-to-severe asthma are associated with fewer genes, which are largely a subset of those associated with childhoodonset asthma. There is significant genetic overlap between asthma and allergic diseases, particularly with respect to childhood-onset asthma, which involves genes that reflect the importance of barrier function biology, and to HLA region genes, which are the most frequently associated genes overall in both groups of diseases. Although the largest GWASs in African American and Latino/Hispanic populations were reported during this period, they are still significantly underpowered compared with studies reported in populations of European ancestry, highlighting the need for larger studies, particularly in patients with childhood-onset asthma and allergic diseases, in these important populations that carry the greatest burden of disease.

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Section: Gwass Of Asthma Remissionmentioning

confidence: 99%

Advances in asthma and allergic disease genetics: Is bigger always better?

Schoettler

Rodríguez

Weidinger

et al. 2019

Journal of Allergy and Clinical Immunology

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“…In our population, the odds of ED management failure was positively associated with the number of risk alleles in these three significant SNPs. Most genetic studies in asthma have focused on the individual effect of a SNP on asthma‐related outcomes . However, the effect size of individual SNPs is often small and thus very large sample sizes are required to detect such effect.…”

Section: Discussionmentioning

confidence: 99%

Genetic determinants of acute asthma therapy response in children with moderate‐to‐severe asthma exacerbations

Tse

Krajinović

Chauhan

et al. 2019

Pediatric Pulmonology

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Background: We documented inter-individual variability in the response to acute asthma therapy in children, attributed in part to five clinical factors (oxygen saturation, asthma severity score, virus detection, fever, symptoms between exacerbations; DOORWAY study). The contribution of genetic determinants of failure of acute asthma management have not been elucidated.Objective: We aim to determine single nucleotide polymorphisms (SNP) associated with emergency department (ED) management failure in children.Methods: A prospective cohort of 591 Caucasian children aged 1-17 years with moderate-to-severe asthma managed with standardized protocol were included. We examined 53 SNPs previously associated with asthma development, phenotypes, or bronchodilator or corticosteroids response. Associations between SNPs and management failure (hospitalization, active asthma management ≥8 h in ED, or a return visit within 72 h for one of two previous criteria) were examined using logistic regression, adjusting for the five clinical predictors of management failure.Results: Four-hundred ninety-one subjects had complete clinical data and usable DNA samples. While controlling for clinical determinants, rs295137 in SPATS2L Trial registration: This study is registered at Clinicaltrials.gov (NCT02013076).

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“…Indeed, the Dutch group has described genetic variants associated with remission across multiple cohorts, while we have previously noted microRNAs predictive of resolution of airways hyperresponsiveness in CAMP. 5,6 We anticipate that by combining clinical and multiomic data using systems biology, we will be able to further elucidate the mechanisms governing asthma remission and persistence. This will enable us to create personalized and more accurate prediction models for asthma remission and may eventually lead to novel therapeutic approaches for the secondary prevention of asthma.…”

Section: Replymentioning

confidence: 99%

Amoxicillin sensitization rate in patients with eruptions after Helicobacter pylori eradication therapy

Kawai¹

2019

Journal of Allergy and Clinical Immunology

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Novel genes and insights in complete asthma remission: A genome‐wide association study on clinical and complete asthma remission

Abstract: By defining a strict remission phenotype, we identified 3 SNPs to be associated with complete asthma remission, where 2 SNPs have plausible biological relevance in FRS2, CCT, IL1RL1, IL18R1 and IL13.

Cited by 19 publications

References 37 publications

Advances in asthma and allergic disease genetics: Is bigger always better?

Advances in asthma and allergic disease genetics: Is bigger always better?

Genetic determinants of acute asthma therapy response in children with moderate‐to‐severe asthma exacerbations

Amoxicillin sensitization rate in patients with eruptions after Helicobacter pylori eradication therapy

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