Novel Generated Peptides for COVID-19 Targets

Rossetto, Allison M.; Zhou, Wenjing

doi:10.1145/3388440.3414919

Cited by 1 publication

(1 citation statement)

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“…Based on their inhibitory potency and selectivity, focusing on high molecular weight compounds over low molecular weight compounds has been advantageous; however, their drug-likeness property is questionable. On the other hand, 11 residues’ long peptide (WWTWTPFHLLV), showed a strong binding affinity compared to α-keto amide inhibitors with a suggested better inhibitory activity over small molecules ( Rossetto and Zhou, 2020 ). Amin et al, 2020 ) analyzed the drug-likeness properties of recently reported SARS-CoV-2 M pro inhibitors.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease

2021

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The Coronavirus disease-19 (COVID-19) pandemic is still devastating the world causing significant social, economic, and political chaos. Corresponding to the absence of globally approved antiviral drugs for treatment and vaccines for controlling the pandemic, the number of cases and/or mortalities are still rising. Current patient management relies on supportive treatment and the use of repurposed drugs as an indispensable option. Of a crucial role in the viral life cycle, ongoing studies are looking for potential inhibitors to the main protease (Mpro) of severe acute respiratory syndrome Coronavirus -2 (SARS-CoV-2) to tackle the pandemic. Although promising results have been achieved in searching for drugs inhibiting the Mpro, work remains to be done on designing structure-based improved drugs. This review discusses the structural basis of potential inhibitors targeting SARS-CoV-2 Mpro, identifies gaps, and provides future directions. Further, compounds with potential Mpro based antiviral activity are highlighted.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%