Novel furan chalcone modulates PHD‐2 induction to impart antineoplastic effect in mammary gland carcinoma
Shubham Rastogi,
Mohd Nazam Ansari,
Abdulaziz S. Saeedan
et al.
Abstract:Normoxic inactivation of prolyl hydroxylase‐2 (PHD‐2) in tumour microenvironment paves the way for cancer cells to thrive under the influence of HIF‐1α and NF‐κB. Henceforth, the present study is aimed to identify small molecule activators of PHD‐2. A virtual screening was conducted on a library consisting of 265,242 chemical compounds, with the objective of identifying molecules that exhibit structural similarities to the furan chalcone scaffold. Further, PHD‐2 activation potential of screened compound was de… Show more
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