Novel functions of Tribbles-homolog 1 in liver, adipocytes and atherosclerosis
Ileana Hernandez-Resendiz,
Ralph Burkhardt
Abstract:Purpose of review
Human genetics studies have sparked great interest in the pseudokinase Tribbles homolog 1, as variant at the TRIB1 gene locus were robustly linked to several cardiometabolic traits, including plasma lipids and coronary artery disease. In this review, we summarize recent findings from mouse models that investigated the function of hepatic and adipocyte Trib1 in lipid metabolism and its role in atherosclerosis.
Recent findings
Studies in… Show more
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