Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals

Elbadawy, Mohamed; Usui, Tatsuya; Yamawaki, Hideyuki; Sasaki, Kenji

doi:10.3390/ijms19103031

Cited by 36 publications

(38 citation statements)

References 109 publications

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“…Understanding the role of CSCs in BC and their regulatory mechanisms may facilitate therapy and provide a better prognosis. In addition, pathways related to EMT (such as Wnt/β-catenin, Notch, and transforming growth factor-beta (TGF-β) [22]), the sonic hedgehog signaling pathway [69,70], the PI3K/AKT pathway [22], MAPKs [71,72], and the JAK-STAT pathway have been implicated in the development and progression of bladder CSCs [73] (Figure 2).…”

Section: Regulatory Pathways Of Bladder Cscsmentioning

confidence: 99%

Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer

Abugomaa

Elbadawy

Yamawaki

et al. 2020

Cells

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Bladder cancer (BC) is a complex and highly heterogeneous stem cell disease associated with high morbidity and mortality rates if it is not treated properly. Early diagnosis with personalized therapy and regular follow-up are the keys to a successful outcome. Cancer stem cells (CSCs) are the leading power behind tumor growth, with the ability of self-renewal, metastasis, and resistance to conventional chemotherapy. The fast-developing CSC field with robust genome-wide screening methods has found a platform for establishing more reliable therapies to target tumor-initiating cell populations. However, the high heterogeneity of the CSCs in BC disease remains a large issue. Therefore, in the present review, we discuss the various types of bladder CSC heterogeneity, important regulatory pathways, roles in tumor progression and tumorigenesis, and the experimental culture models. Finally, we describe the current stem cell-based therapies for BC disease.

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Section: Regulatory Pathways Of Bladder Cscsmentioning

confidence: 99%

Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer

Abugomaa

Elbadawy

Yamawaki

et al. 2020

Cells

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“…However, other novel AD tau associated kinases identified in this study, beyond TBK1 (i.e., DAPK3 and TNIK), also warrant future investigation in their ability to phosphorylate and modify tau. For example, death-associated protein kinase-3 (DAPK3) is a Ca2+/calmodulin (CaM)-regulated serine/threonine kinases with roles in autophagy (64) and TNIK (65) has key roles in dendritic spine structure. Thus, we would hypothesize that tau is a direct substrate for these kinases and has key roles related to the respective functions of DAPK3 and TNIK in brain.…”

Section: Discussionmentioning

confidence: 99%

TBK1 interacts with tau and enhances neurodegeneration in tauopathy

Abreha

Ojelade

Dammer

et al. 2020

Preprint

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Running title: TBK1 is a tau-directed kinase Key words: TANK-binding kinase 1 (TBK1), microtubule associated protein tau (MAPT), neurofibrillary tangles (NFTs), Alzheimer's disease (AD), familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), co-immunoprecipitation (co-IP), mass spectrometry (MS), post-translational modification (PTM), Drosophila, IκB kinase (IKK) ABSTRACT One of the defining pathological features of Alzheimer's Disease (AD) is the deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau in the brain. Aberrant activation of kinases in AD has been suggested to enhance phosphorylation and toxicity of tau, making the responsible taudirected kinases attractive therapeutic targets. The full complement of tau interacting kinases in AD brain and their activity in disease remains incompletely defined.Here, immunoaffinity enrichment coupled with mass spectrometry (MS) identified TANKbinding kinase 1 (TBK1) as a tau-interacting partner in human AD cortical brain tissues. We validated this interaction in both human AD and familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) caused by mutations in MAPT (R406W) postmortem brain tissues as well as human cell lines. Further, we document increased TBK1 activity in both AD and FTDP-17 and map the predominant TBK1 phosphorylation sites on tau based on in vitro kinase assays coupled to MS. Lastly, in a Drosophila tauopathy model, activating expression of a conserved TBK1 ortholog triggers tau hyperphosphorylation and enhanced neurodegeneration, whereas knockdown had the reciprocal effect, suppressing tau toxicity. Collectively, our findings suggest that increased TBK1 activity may promote tau hyperphosphorylation and neuronal loss in AD and related tauopathies.

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“…Examples of these cell lines are LNCaP [41,42], PC-3 [43,44], DU145 [45,46],VCaP [47,48], NCI-H660 [49], PC346 [50], 22Rv1 [51], KUCaP [52], MDA PCa 2a and MDA PCa 2b [53,54]. Among them, DU145, PC-3, and LNCaP are the most widely used ones in PC research [55,56].…”

Section: Pc Cell Linesmentioning

confidence: 99%

Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research

Elbadawy

Abugomaa

Yamawaki

et al. 2020

Cancers

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Prostate cancer (PC) is the most prevalent cancer in men and the second main cause of cancer-related death in Western society. The lack of proper PC models that recapitulate the molecular and genomic landscape of clinical disease has hampered progress toward translational research to understand the disease initiation, progression, and therapeutic responses in each patient. Although several models have been developed, they hardly emulated the complicated PC microenvironment. Precision medicine is an emerging approach predicting appropriate therapies for individual cancer patients by means of various analyses of individual genomic profiling and targeting specific cancer pathways. In PC, precision medicine also has the potential to impose changes in clinical practices. Here, we describe the various PC models with special focus on PC organoids and their values in basic medicine, personalized therapy, and translational researches in vitro and in vivo, which could help to achieve the full transformative power of cancer precision medicine.

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Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals

Cited by 36 publications

References 109 publications

Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer

Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer

TBK1 interacts with tau and enhances neurodegeneration in tauopathy

Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research

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