Novel Fucoidan Pharmaceutical Formulations and Their Potential Application in Oncology—A Review

Abstract

Fucoidan belongs to the family of marine sulfated, L-fucose-rich polysaccharides found in the cell wall matrix of various brown algae species. In the last few years, sulfated polysaccharides have attracted the attention of researchers due to their broad biological activities such as anticoagulant, antithrombotic, antidiabetic, immunomodulatory, anticancer and antiproliferative effects. Recently the application of fucoidan in the field of pharmaceutical technology has been widely investigated. Due to its low toxicity, biocompatibility and biodegradability, fucoidan plays an important role as a drug carrier for the formulation of various drug delivery systems, especially as a biopolymer with anticancer activity, used for targeted delivery of chemotherapeutics in oncology. Furthermore, the presence of sulfate residues with negative charge in its structure enables fucoidan to form ionic complexes with oppositely charged molecules, providing relatively easy structure-forming properties in combination with other polymers. The aim of the present study was to overview essential fucoidan characteristics, related to its application in the development of pharmaceutical formulations as a single drug carrier or in combinations with other polymers. Special focus was placed on micro- and nanosized drug delivery systems with polysaccharides and their application in the field of oncology.

Algae-Based Nanoparticles for Oral Drug Delivery Systems

“…Several mucoadhesive natural biopolymers (e.g., alginate [ 19 ], carrageenan [ 19 ], and fucoidan [ 20 ]) are major components in algae. Thus, we used the biomimetic approach and produced NPs directly from algae, assuming it would impart these NPs with mucoadhesiveness [ 21 ]. Additionally, edible algae are of great interest to drug delivery research due to their inherent biodegradability, non-immunogenicity, and biodegradability [ 22 ].…”