Novel Free-Circulating and Extracellular Vesicle-Derived MiRNAs Dysregulated in Duchenne Muscular Dystrophy

Catapano, Francesco; Scaglioni, Dominic; Maresh, Kate; Ala, Pierpaolo; Domingos, Joana; Selby, V.; Ricotti, Valeria; Phillips, Lauren; Servais, Laurent; Seferian, A.; Groot, I. de; Krom, Yvonne D.; Voït, Thomas; Verschuuren, Jan J.; Niks, Erik H.; Straub, Volker; Morgan, Jennifer E.; Muntoni, Francesco

doi:10.2217/epi-2020-0052

Cited by 6 publications

(5 citation statements)

References 62 publications

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“…But non-coding RNAs in EVs show remarkable stability and more durable activity, and have good RNase degradation resistance. And a higher expression of the EV-derived miRNA pool is likely to result from a shell-like protective activity exerted by the EVs on miRNAs in plasma ( 131 ). More importantly, among the EV bioactive cargoes, non-coding RNAs in EVs are an important component of gene regulation, eliciting either decay or translational repression of target mRNAs while free non-coding RNAs do not have it ( 132 ).…”

Section: Discussionmentioning

confidence: 99%

The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: Trends and prospects

Deng

Chen

2022

Front. Endocrinol.

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Diabetic foot ulcer(DFU) is one of the most severe chronic complications of type 2 diabetes mellitus, which is mainly caused by peripheral vascular occlusion with various degrees of infection. Treatment of DFU is difficult, and ulcer formation in lower limbs and deep-tissue necrosis might lead to disability or even death. Insulin resistance is the major mechanism of type 2 diabetes mellitus development, largely caused by adipose tissue dysfunction. However, adipose tissue was recently identified as an important endocrine organ that secretes bio-active factors, such as adipokines and extracellular vesicles(EVs). And adipose tissue-derived stem cells(ADSCs) are abundant in adipose tissue and have become a hot topic in the tissue engineering field. In particular, EVs derived from ADSCs contain abundant biomarkers and mediators. These EVs exert significant effects on distant cells and organs, contributing to metabolic homeostasis. In this review, we aim to elaborate on the mechanisms of diabetic non-healing wound development and the role of ADSCs-EVs in wound repair, which might provide a new therapy for treating DFU.

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Section: Discussionmentioning

confidence: 99%

The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: Trends and prospects

Deng

Chen

2022

Front. Endocrinol.

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“…On the other hand, miR-21-5p and miR-23b-3p decreased in non-ambulant patients with DMD compared with healthy controls [ 93 ]. The same group also assessed both free-circulating miRNAs as well as miRNAs derived from extracellular vesicles (EVs) in serum [ 94 ]. Regarding the free-circulating miRNAs, they found upregulation of miR-1-3p, miR-133a-3p, and miR-29c-3p in patients with DMD compared with healthy controls.…”

Section: Microrna Alterations In Duchenne Muscular Dystrophymentioning

confidence: 99%

The Role of MicroRNA in the Pathogenesis of Duchenne Muscular Dystrophy

Kiełbowski,

Bakinowska,

Procyk

et al. 2024

IJMS

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Duchenne muscular dystrophy (DMD) is an X-linked progressive disorder associated with muscle wasting and degeneration. The disease is caused by mutations in the gene that encodes dystrophin, a protein that links the cytoskeleton with cell membrane proteins. The current treatment methods aim to relieve the symptoms of the disease or partially rescue muscle functionality. However, they are insufficient to suppress disease progression. In recent years, studies have uncovered an important role for non-coding RNAs (ncRNAs) in regulating the progression of numerous diseases. ncRNAs, such as micro-RNAs (miRNAs), bind to their target messenger RNAs (mRNAs) to suppress translation. Understanding the mechanisms involving dysregulated miRNAs can improve diagnosis and suggest novel treatment methods for patients with DMD. This review presents the available evidence on the role of altered expression of miRNAs in the pathogenesis of DMD. We discuss the involvement of these molecules in the processes associated with muscle physiology and DMD-associated cardiomyopathy.

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“…As stated previously, for now, miRNAs appear to represent the most consequential population of EV cargos. This applies not only to the myomiRs, but also to more ubiquitously expressed miRNAs ( Catapano et al, 2020 ). In animal models of DMD, some miRNAs have been found to be significantly up- or downregulated ( Yedigaryan & Sampaolesi, 2021 ).…”

Section: The Role Of Extracellular Vesicles In the Duchenne Muscular ...mentioning

confidence: 99%

Extracellular vesicles and Duchenne muscular dystrophy pathology: Modulators of disease progression

Yedigaryan

Sampaolesi

2023

Front. Physiol.

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Duchenne muscular dystrophy (DMD) is a devastating disorder and is considered to be one of the worst forms of inherited muscular dystrophies. DMD occurs as a result of mutations in the dystrophin gene, leading to progressive muscle fiber degradation and weakness. Although DMD pathology has been studied for many years, there are aspects of disease pathogenesis and progression that have not been thoroughly explored yet. The underlying issue with this is that the development of further effective therapies becomes stalled. It is becoming more evident that extracellular vesicles (EVs) may contribute to DMD pathology. EVs are vesicles secreted by cells that exert a multitude of effects via their lipid, protein, and RNA cargo. EV cargo (especially microRNAs) is also said to be a good biomarker for identifying the status of specific pathological processes that occur in dystrophic muscle, such as fibrosis, degeneration, inflammation, adipogenic degeneration, and dilated cardiomyopathy. On the other hand, EVs are becoming more prominent vehicles for custom-engineered cargos. In this review, we will discuss the possible contribution of EVs to DMD pathology, their potential use as biomarkers, and the therapeutic efficacy of both, EV secretion inhibition and custom-engineered cargo delivery.

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Novel Free-Circulating and Extracellular Vesicle-Derived MiRNAs Dysregulated in Duchenne Muscular Dystrophy

Cited by 6 publications

References 62 publications

The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: Trends and prospects

The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: Trends and prospects

The Role of MicroRNA in the Pathogenesis of Duchenne Muscular Dystrophy

Extracellular vesicles and Duchenne muscular dystrophy pathology: Modulators of disease progression

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