Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease

Yadav, Vivek R.; Suresh, Sarasija; Devi, Kshama; Yadav, Seema

doi:10.1211/jpp/61.03.0005

Cited by 35 publications

(29 citation statements)

References 28 publications

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“…Treated group with SLM curcumin showed a faster weight gain than the DSS control additionally it showed predominance of eosinophils in the chronic cell infiltrate. The above in vivo studies showed that degree of colitis caused by administration of DSS was significantly attenuated by colonic delivery of SLMs of curcumin 36 .…”

Section: Fig 2: Release Mechanism Of Microparticlesmentioning

confidence: 84%

Untitled

2017

IJPSR

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Now a day's world health organisation encourage, recommends and promotes traditional, herbal remedies in health care science, because these drugs are easily available at low cost and are safe but herbal medicines are not a simple task since many factor influence biological efficacy and reproducible therapeutic effect. These day's colonic diseases are commonly seen and needs lifelong medical attention. Because of safety, herbal medicines can play vital role in the treatment of colonic diseases. Various natural therapies, available for the treatment of colonic diseases like ulcerative colitis, Intestinal bowel syndrome, colon cancer, etc. It is possible to improve the effect of these herbal medicines by targeting to the colon. This article review a detailed study about various pharmaceutical approaches used for colon targeting such as tablet, capsules, microparticles, micro-sponges, lyposomes, etc. with herbal drugs and their effects. Effects of different process and formulation parameters on colon targeted drug delivery system are also discussed in following article.

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Section: Fig 2: Release Mechanism Of Microparticlesmentioning

confidence: 84%

Untitled

2017

IJPSR

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“…Previously described formulations include microsponges [10], microspheres [11], solid lipid microparticles [12], cyclodextrin complexes [13] and curcumin-inclusion complex tablets with pH-and enzyme-sensitive polymer coating [14]. While Beloqui et al [7] formulated curcumin-NPs using conventional synthetic poly (lactide-co-glycolide) (PLGA) and polymethacrylate (Eudragit ® S100), Gugulothu et al.…”

Section: Introductionmentioning

confidence: 99%

Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin

Mutalik

Suthar

Managuli

et al. 2016

International Journal of Biological Macromolecules

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Inflammatory bowel disease (IBD) is an inflammatory condition with mucosal ulceration, edema and hemorrhage of gastrointestinal tract. Curcumin has been shown to mitigate colitis in animal models.However, its usefulness is reduced due to poor pharmacokinetic behavior and low oral bioavailability. To address this, novel pH-sensitive hydrolyzed polyacrylamide-grafted-xanthan gum (PAAm-g-XG) nanoparticles (NPs) loaded with curcumin were prepared for colonic delivery.Optimized nanoparticles (CN20) were spherical, with an average size of 425 nm. A negligible amount of curcumin (≈8%) was released from CN20 NPs in pH 1.2 and 4.5 solutions. When the pH was increased to 7.2, curcumin release was comparatively faster than that observed with pH 1.2 and 4.5 collectively. In pH 6.8 solution, excellent release of curcumin was observed. Highest curcumin release was observed when rat caecal contents were incorporated in pH 6.8 solution, indicating microflora-dependent drug release property of NPs. In acetic acid-induced IBD in rats, curcumin NPs reduced myeloperoxidase and nitrite levels, prevented weight loss and attenuated colonic inflammation. Curcumin was better absorbed systemically in nanoparticulate form with increased C max (~3 fold) and AUC (~2.5 fold) than when delivered as free curcumin. We demonstrate successful development of grafted co-polymeric NPs containing drug suitable for colon targeting.

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“…The bioavailability and biocompatibility of curcuminoids could be significantly improved, if administered intrarectal [13,14]. Conventional suppositories are solids at room temperature and melt or soften at body temperature, due to the characteristics; patients feel discomfort, and prefer oral administration of drugs, rather than via suppositories [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention

Chen

Cheng

Lai

et al. 2012

Int J Colorectal Dis

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Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease

Abstract: The degree of colitis caused by administration of DSS was significantly attenuated by colonic delivery of SLMs of curcumin. Being a nontoxic natural dietary product, curcumin could be useful in the therapeutic strategy for inflammatory bowel disease patients.

Cited by 35 publications

References 28 publications

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Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin

In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention

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