Novel fluoroquinolones: design, synthesis, and in vivo activity in mice against Mycobacterium tuberculosis H37Rv

Shindikar, A. V.; Viswanathan, C. L.

doi:10.1016/j.bmcl.2005.02.037

Cited by 61 publications

(39 citation statements)

References 8 publications

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“…Novel fluoroquinolones 49 containing a hydrazone structure were synthesized and evaluated in vivo against M. tuberculosis H37Rv in Swiss albino mice by Shindikar et al Results of the study indicate the potent antitubercular activity of the test compouds [52]. N-[2-oxo-2-(4-aryl-piperazin-1-yl)ethyl]hydrazide derivatives 50 containing INH hydrazide-hydrazones were synthesized and evaluated antimycobacterial activity against M. tuberculosis H37Rv ATCC 27294 and M. tuberculosis clinical isolates.…”

Section: -48mentioning

confidence: 99%

Biological Activities of Hydrazone Derivatives

2007

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There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH-proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

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Section: -48mentioning

confidence: 99%

Biological Activities of Hydrazone Derivatives

2007

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“…No cross-resistance with other anti-TB agents occurs. In studies based on sequencing the genomes of susceptible and resistance strains, to find the cellular target, the only difference found is in the atpE gene which codes for the proton pump associated with ATP synthase [42,43].…”

Section: Diarylquinolinesmentioning

confidence: 99%

Development of nitroimidazopyrans and nitroimidaoxazoles for tuberculosis chemotherapy

Asif

2014

El Med J

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“…Moxifloxacin and gatifloxacin d gram-negative bacteria, including anaerobes. It inhibits bacterial DNA gyrase, an enzyme that is essential for the maintenance of DNA supercoils, which are necessary for chromosomal replication (Shindikar & Viswanathan, 2005). The development of mycobacterial resistance to fluoroquinolones has been described in MDR strains and in strains from HIV-infected TB patients with a low CD4 count (Shandil et al, 2007).…”

Section: Moxifloxacin and Gatifloxacinmentioning

confidence: 99%