Novel Fluoro Substituted Benzo[b]pyran with anti‐Lung Cancer Activity.

Abstract

2005 Benzopyran derivatives R 0350 Novel Fluoro Substituted Benzo[b]pyran with anti-Lung Cancer Activity. -The majority of the products (no yields given) exhibits lung anticancer activity at low concentration comparable with that of the reference drug 5-fluorodeoxyuridine. -(HAMMAM*, A. E.-F. G.; EL-SALAM, O. I. A.; MOHAMED, A. M.; HAFEZ, N. A.; Indian J.

Studies on synthetic and structural characterization of new fluorine substituted phthalides of pharmaceutical interest

“…They are isosteric to parent hydrocarbons and show improved lipophilicity as well as inertness to metabolic transformations [4][5][6] . Large number of fluorinated organic compounds exhibit antimicrobial 7,8 , antitumour and anti lung cancer 9 activities. Some fluorinated chalcone derivatives are reported to possess anti-inflammatory activity due to their influence on nitric oxide production 10 .…”

Design, Synthesis, Antitumor activity, cell cycle analysis and ELISA assay for Cyclin Dependant Kinase-2 of a new (4-aryl-6-flouro-4H-benzo[4, 5] thieno[3, 2-b] pyran) derivatives.

“…4-4-Subsituted Phenyl ring more active than heterocyclic ring as naphthyl ring 14 . 5-Amino group in compound 4b and imine group in compound 6 at C-2 give a comparable activity.…”

“…Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA14-1) an antagonist for ant apoptotic Bcl-2 proteins was used to overcome drug resistance in cancer. Recently, screening anticancer activity of 2-amino-6-bromo-4-(4-nitrophenyl)-4H-benzo [4,5]thieno [3,2-b]pyran-3-carbonitrile using HCT-116 cell line produced a good anticancer activity and also proved to induce apoptosis at G0/G1 phase 13 .The present work is aimed towards construction of novel heterocyclic compounds of anticipated anticancer activity and to compare anticancer screening result of 2-amino-6-bromo-4-(4-nitrophenyl)-4H- [1]benzothieno [3,2-b]pyran-3-carbonitrile with our target compounds by replacing bromine atom at position 6 with fluorine atom which possess higher electronegativity, higher thermal stability and higher lipophilicity than bromine atom 14 . Figure 1.…”

BIOCHEMICAL CHARACTERIZATION OF VOLATILE SECONDARY METABOLITES PRODUCED BY Burkholderia gladioli pv. agaricicola

“…On the other hand, Hossain, et al [16] have characterized the bioactivity of the extracted essential oils of Orthosiphon stamineus which has showed a remarkable antifungal effect against some phytopathogenic fungi due to the presence of caryophyllene, humulene, elemene, bourbonene, pinene, caryophyllene oxide, camphene and limonene. [17,18], antibacterial [19], antifungal [20], antiviral [21], antihypertensive [22], antioxidants [22], anti-inflammatory [22], anti-lung cancer [23] and antiviral [21] effects. Kamboj, et al [24] evaluated the antimicrobial activity of some flavanone compounds against some pathogenic bacteria and fungi and concluded that all tested flavanones exhibited antibacterial and antifungal activity against some G+ve bacteria Staphylococcus aureus and Bacillus subtilis.…”