Novel fluorescent nitrogen-doped carbon dots derived from Panax notoginseng for bioimaging and high selectivity detection of Cr⁶⁺

Abstract

Schematic of the synthetic route to fluorescent Pn-CDs and Pn N-CDs and their applications in the bioimaging and detection of Cr6+.

Herbal medicine derived carbon dots: synthesis and applications in therapeutics, bioimaging and sensing

“…The BBB penetration mechanism is classified into active transport and passive transport [ 89 ]. In the HM-CDs, one report noted that Pn-CDs could cross the BBB, which may be due to the ultra-small size, abundant surface functional groups, and the strong affinity to endothelial cell membrane of BBB [ 38 ]. But the molecular uptake mechanisms of Pn-CDs should be further evaluated.…”

“…CDs derived from Panax notoginseng ( Sanqi ) for mammalian fluorescence imaging were not found until 2020 [ 38 ]. Compared with live cell imaging, in vivo live imaging tends to a clinical transformation.…”

“…They only found that IFE but not electron transfer was associated with fluorescence quenching. Furthermore, Panax notoginseng carbon dots (Pn-CDs) also detected Cr 6+ via IFE, and the DL was 0.185 nM [ 38 ].…”

“…Next to cellular imaging, few HM-CDs were applied to other biological imaging. A classic example is nitrogen-doped Pn-CDs [ 38 ], which was used for fluorescence imaging of multiple organisms. In microorganism imaging, Pn-CDs clearly labeled E. coli, B. cereus and S. cerevisiae .…”

Sustainable and Green Synthesis of Waste-Biomass-Derived Carbon Dots for Parallel and Semi-Quantitative Visual Detection of Cr(VI) and Fe3+

“…UV-vis and fluorescence spectra were investigated to further observe the optical behavior of the FW-CDs. The UV-vis spectrum of the FW-CDs (the black line in Figure 2a) showed two absorption peaks centered at 258 nm and 330 nm, which might be caused by the π-π* energy transition of conjugated C=C bonds [58] and the n-π* transition of the structure of the C=O/C=N groups [59]. On the other hand, Figure 2a shows that the FW-CDs had the strongest fluorescent emission at 445 nm under 375 nm excitation.…”