Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA

Lu, Xiaoju; Meng, Lingzhi; Zhong, Xia

doi:10.3144/expresspolymlett.2007.50

Cited by 3 publications

(2 citation statements)

References 26 publications

(27 reference statements)

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“…Amphiphilic block copolymers have been widely reported to form particulate systems of various morphologies such as spherical or worm-like micelles, polymersomes, large compound micelles, lamellae, and numerous other aggregates [1][2][3][4][5][6][7][8]. Among these morphologies, polymersomes are particularly interesting for their potential applications as carriers of biological therapeutics and diagnostic agents [9,10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and self-assembly behavior of amphiphilic diblock copolymer dextran-block-poly(ε-caprolactone) (DEX-b-PCL) in aqueous media

Zhang¹,

Dou²,

Jin³

2010

Express Polym. Lett.

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Abstract. An amphiphilic diblock copolymer, dextran-block-poly(ε-caprolactone) (DEX-b-PCL), with a series of welldefined chain lengths of each block was prepared by conjugating a dextran chain with a PCL block via aza-Michael addition reaction under mild conditions. For the dextran block, samples with relatively uniform molecular weight, 3.5 and 6.0 kDa, were used, and the PCL blocks were prepared via ring-opening polymerization at defined ratios of ε-caprolactone to initiator in order to give copolymers with mass fraction of dextran (fDEX) ranging from 0.16 to 0.45. When these copolymers were allowed to self-assemble in aqueous solution, the morphology of assembled aggregates varied as a function of fDEX when characterized by transmission electron microscope (TEM), fluorescence microscope (FM) and dynamic laser scattering (DLS). As fDEX decreases gradually from 0.45 to 0.16, the morphology of the copolymer assembly changes from spherical micelles to worm-like micelles and eventually to polymersomes, together with an increase in particle sizes.

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Section: Introductionmentioning

confidence: 99%

Synthesis and self-assembly behavior of amphiphilic diblock copolymer dextran-block-poly(ε-caprolactone) (DEX-b-PCL) in aqueous media

Zhang¹,

Dou²,

Jin³

2010

Express Polym. Lett.

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“…ATRP is an excellent and well-established method for obtaining block copolymers using simple experimental protocols and a large variety of the available monomers, especially for preparation of amphiphilic block copolymers with well-defined architecture and narrow molecular weight distribution [43][44][45][46][47][48][49][50]. This example demonstrates, in the best way, the features that must be considered for a successful employment of ATRP in block copolymer synthesis.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Preparation and self-assembly behavior of polystyrene-block-poly (dimethylaminoethyl methacrylate) amphiphilic block copolymer using atom transfer radical polymerization

Zhu¹,

Tan²,

Du³

2008

Express Polym. Lett.

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Asymmetric and semi-symmetric amphiphilic diblock copolymers polystyrene-block-poly (dimethylaminoethyl methacrylate) (PS-b-PDMAEMA) with the same PS block length of 62 repeat units and quite short (3 repeat units) or equivalent (47 repeat units) length of PDMAEMA have been prepared simply by varying the ratio of the bromine-terminated macroinitiator polystyrene (PS-Br) to DMAEMA using atom transfer radical polymerization (ATRP). The chemical structures and compositions of the PS-b-PDMAEMA block copolymers are studied by nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), and elementary analysis (EA). The self-assembly behaviors of copolymers in N,N-dimethyl formamide (DMF) with different pH and dioxane/water binary solvent mixture by direct dissolution method (DD), are studied by transmission electron microscopy (TEM), electron diffracting analysis (EDA), and energy-dispersive analysis of X-rays (EDAX) techniques. Transmission electron microscopy results suggest that asymmetric block copolymer PS62-b-PDMAEMA3 (the numbers in the form of footnotes represent repeated units of each monomer in the copolymer) can form spherical core-shell micelles, large compound reverse micelles (LCRMs), hexagonal/rhombic phases, reverse hexagonal/rhombic phases, vesicles, reverse vesicles and necklace-like reverse micelles, controlled by common or selective solvent and pH, while most of the aggregates of semi-symmetric PS62-b-PDMAEMA47 are simply spherical, such as spherical core-shell micelles and reverse spherical core-shell micelles, besides hexagonal/rhombic phases. All above structures are controlled by three components of the free energy of aggregation: core-chain stretching, interfacial energy and intercoronal chain interaction

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Novel Amphiphilic Poly(N‐vinylpyrrolidone) Block Copolymer: Aggregative Behavior and Interaction with DNA

Zhang

Meng

et al. 2008

Macromolecular Symposia

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Novel block copolymers poly(N-vinylpyrrolidone)-block-poly[(tert-butoxy) carbonyl] tryptophanamido-N 0 -methacryl thiourea (PVP-b-PTAM-I, II and III) were synthesized by atom transfer radical polymerization (ATRP) in DMF using PVP-Cl as macroinitiator. The structures of the copolymers were characterized by UV-vis and GPC-MALLS. The results revealed that the copolymers with controlled molecular weight and relatively low polydispersity (PDI < 1.34) were obtained through ATRP. By means of dynamic light scattering (DLS) and transmission electron microscopy (TEM), we demonstrated that copolymer PVP-b-PTAM self-aggregated to form spherical micelles in aqueous solution and the size of the micelles increased with increasing hydrophobic contents. The interaction of PVP-b-PTAM with DNA was explored using ethidium bromide (EB) quenching experiments. The interaction between PVP-b-PTAM and DNA markedly depended on both the copolymer concentration and composition. The PVP-b-PTAM-II and III with higher hydrophobic contents exhibited highly complexed DNA ability at low copolymer concentration, such as 0.017 mg/mL, relative to PVP-b-PTAM-I. As the copolymer concentration further increased for PVP-b-PTAM-II and III, they first exhibited a sharply decreased affinity for DNA and then kept steady. The interaction mechanism between the amphiphilic copolymers and the EB-DNA complex was discussed in detail.

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Novel fluorescent amphiphilic block copolymers: photophysics behavior and interactions with DNA

Cited by 3 publications

References 26 publications

Synthesis and self-assembly behavior of amphiphilic diblock copolymer dextran-block-poly(ε-caprolactone) (DEX-b-PCL) in aqueous media

Synthesis and self-assembly behavior of amphiphilic diblock copolymer dextran-block-poly(ε-caprolactone) (DEX-b-PCL) in aqueous media

Preparation and self-assembly behavior of polystyrene-block-poly (dimethylaminoethyl methacrylate) amphiphilic block copolymer using atom transfer radical polymerization

Novel Amphiphilic Poly(N‐vinylpyrrolidone) Block Copolymer: Aggregative Behavior and Interaction with DNA

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