2024
DOI: 10.21203/rs.3.rs-5025191/v1
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Novel flavonoid derivatives containing benzothiazole as potential antiviral agents: design, synthesis, and biological evaluation

Jiao Tian,
Chunmei Hu,
Yuhong Wang
et al.

Abstract: A series of flavonol derivatives containing benzothiazole were designed and synthesized. The structures of all the compounds were characterized by NMR and HRMS. The results of the bioactivity assay showed that some of the target compounds possessed outstanding in vivo antiviral activity against the tobacco mosaic virus (TMV). Among them, the median effective concentration (EC50) of L20 was 90.5 µg/mL for curative activities against TMV, which was better than that of ningnanmycin (NNM: 252.0 µg/mL). The microca… Show more

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