Novel Flavones from the Root of Phytolacca acinosa Roxb.

Abstract

Two new flavones, 6,7-methylenedioxy-4-hydroxypeltogynan-7'-one (1), cochliophilin B (2), as well as two known ones, cochliophilin A (3) and 6-methoxy-7-hydroxy flavone (4), were isolated from the ethanol extract of the root of Phytolacca acinosa Roxb. Compound 1 is a flavanol framework with one δ-lactone unit, which is rather rare in nature. The structures of the new compounds were determined on the basis of extensive spectroscopic (IR, MS, 1D- and 2D-NMR) analyses, the absolute configuration of 1 was established by comparing experimental and calculated electronic circular dichroism spectra. The structures of known compounds were fixed by comparison with literatures data. Compounds 2 and 4 showed modest inhibitory activities against BEL-7402 cell line, with IC values of 28.22 and 39.16 μmol/L, respectively.

Carotenoid and Phenolic Profiles and Antioxidant and Anticholinesterase Activities of Leaves and Berries of Phytolacca acinosa

“…The purified sample of P. acinosa has 92.0% polysaccharide, while unpurified samples contain 60.84% polysaccharide and 10.8% protein . Flavonoids, such as 6,7-methylenedioxy-4-hydroxypeltogynan-7′-one, cochliophilin B, cochliophilin A, and 6-methoxy-7-hydroxyflavone, have been reported in the roots of P. acinosa . Some of these compounds showed inhibition of the BEL-7402 cell line.…”

“…4 Flavonoids, such as 6,7-methylenedioxy-4hydroxypeltogynan-7′-one, cochliophilin B, cochliophilin A, and 6-methoxy-7-hydroxyflavone, have been reported in the roots of P. acinosa. 5 Some of these compounds showed inhibition of the BEL-7402 cell line. Phytolaccagenin was identified and quantified in the dried roots of P. acinosa using HPLC-MS/MS.…”

Vegetative propagation of Phytolacca acinosa Roxb. by rhizome cuttings: a step towards conservation and cultivation approach

“…Consequently, it serves as an important medicinal herb with diverse pharmacological properties like antibacterial, anti-fungal, anti-inflammatory, antiviral, anti-oxidative, anticancer, immunity-enhancing, anti-parasitic, and insecticidal properties (Gao et al, 2009;Cheng et al, 2017;Bailly, 2021). It has been reported to exhibit cytotoxicity in human cancer cell lines and antimicrobial activity in bacterial culture (Ma et al, 2017(Ma et al, , 2019Krishan et al, 2022). Besides being used as medicine, P. acinosa is also used as a source of food, red dye for coloring wool fabric, and for phytoremediation of heavy metals like cadmium (Cd), lead (Pb), manganese (Mn), and zinc (Zn) (Zhao et al, 2014;Wu et al, 2016;Liu et al, 2022).…”

Phyto-ecological analysis of Phytolacca acinosa Roxb. assemblages in Kashmir Himalaya, India

“…It is native to Himalaya, east and southeast Asia including Myanmar, China, Taiwan, Bhutan, Japan, Tibet, Vietnam, Manchuria, India, and Korea mostly growing along roadsides, inside forests and forest margins at the elevation of 500-3400 m (POWO., 2022). P. acinosa has immense medicinal importance and is widely used as a diuretic in Chinese folk medicine system and treatment of various diseases such as swelling, edema, indigestion, eye disorder, body ache, and sores (Ma et al, 2017;Basnet and Kalauni, 2020). P. acinosa contains many phytochemicals including tannins, flavonoids, polyphenol, triterpenoids, flavones, saponins, tannic and phenolic compounds (Lin et al, 2018;Ma et al, 2019;Tao et al, 2020).…”