Novel Fish Oil-based Bigel System for Controlled Drug Delivery and its Influence on Immunomodulatory Activity of Imiquimod Against Skin Cancer

Rehman, Khurram; Zulfakar, Mohd Hanif

doi:10.1007/s11095-016-2036-8

Cited by 54 publications

(39 citation statements)

References 37 publications

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“…The omega-3 PUFAs served as the inducers of IL-10, an anti-inflammatory cytokine, and as the suppressors of IL-6 and TNF-α to depress cell growth. Rehman and Zulfakar [71] further developed the imiquimod-loaded fish oil bigel colloidal delivery system for treating skin cancer in a mouse model. Bigel is defined as an intimate hydrogel/oleogel colloidal semisolid vehicle for topical application [72].…”

Section: Fatty Acids For Skin Disorder Prevention and Treatmentmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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Fish oil has been broadly reported as a potential supplement to ameliorate the severity of some skin disorders such as photoaging, skin cancer, allergy, dermatitis, cutaneous wounds, and melanogenesis. There has been increasing interest in the relationship of fish oil with skin protection and homeostasis, especially with respect to the omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The other PUFAs, such as α-linolenic acid (ALA) and linoleic acid (LA), also show a beneficial effect on the skin. The major mechanisms of PUFAs for attenuating cutaneous inflammation are the competition with the inflammatory arachidonic acid and the inhibition of proinflammatory eicosanoid production. On the other hand, PUFAs in fish oil can be the regulators that affect the synthesis and activity of cytokines for promoting wound healing. A systemic review was conducted to demonstrate the association between fish oil supplementation and the benefits to the skin. The following describes the different cosmetic and therapeutic approaches using fatty acids derived from fish oil, especially ALA, LA, DHA, and EPA. This review summarizes the cutaneous application of fish oil and the related fatty acids in the cell-based, animal-based, and clinical models. The research data relating to fish oil treatment of skin disorders suggest a way forward for generating advances in cosmetic and dermatological uses.

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Section: Fatty Acids For Skin Disorder Prevention and Treatmentmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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“…Olive oil [2], sesame oil [4,5], sunflower oil [6], soybean oil [1,7] and fish oil [8,9] are the most commonly used oils for bigel preparation. Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%

“…Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Andonova¹,

Peneva²,

Apostolova³

et al. 2017

Trop. J. Pharm Res

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“…In recent years, many scientists have proposed the development of formulations by mixing hydrogels and oleogels. Such formulations are regarded as bigels (Rehman & Zulfakar, ; Rehman et al, ). Since hydrogels are polar and oleogels are apolar, bigels may be regarded as emulsions having both internal and external immobilized phases (Kodela et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Based on the results, the authors proposed that the developed bigels can be used as carriers for controlled delivery applications. Recently, Rehman and Zulfakar () reported the development of imiquimod–fish‐oil‐based bigels as a topical drug delivery vehicle. The authors further suggested that the bigel system could be useful in controlling the inflammation caused as a side effect of imiquimod administration, apart from helping in the treatment of skin cancer.…”

Section: Introductionmentioning

confidence: 99%

Development of Bigels Based on Stearic Acid–Rice Bran Oil Oleogels and Tamarind Gum Hydrogels for Controlled Delivery Applications

Paul

Qureshi

Yogalakshmi

et al. 2018

J Surfact & Detergents

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In the last few decades, different types of gels have been widely studied as potential drug delivery carriers. In this paper, we propose the synthesis of an oleogel, a tamarind gum hydrogel, and bigels for applications as drug delivery matrices. The oleogel was prepared by mixing stearic acid and rice bran oil, whereas the hydrogel was prepared by mixing tamarind gum with a hydroethanolic solution. Hydrogel-in-oleogel and oleogel-in-hydrogel bigels were prepared by mixing the hydrogel and the oleogel. The suitability of the formulations for controlled drug release applications was thoroughly examined using microscopy, Fourier transform infrared (FTIR) spectroscopy, as well as mechanical, electrical, thermal, drug release, and antimicrobial studies. An alteration in the microarchitecture of the bigels is observed when the oleogel and the hydrogel are mixed in varying proportions. The associative interactions within the formulations increase with the increase in the hydrogel content. The bigels exhibit the presence of stearic acid melting endotherm (associated with the oleogel) and water evaporation endotherm (associated with the hydrogel). This study suggests that the hydrogel has lowest bulk resistance compared to the other formulations. The structural breakdown of the bigels is composition-dependent, and the bulk electrical resistance is mainly governed by the oleogel phase. An increase in the diffusion of the moxifloxacin HCl from the formulations is observed with the increase of the hydrogel proportion, which in turn increases the rate of release of the drug. The proposed formulations also exhibit good antimicrobial efficacy. The analysis of these properties suggests that specific formulations can be tailored by need-based applications of the drug release rate.Keywords Oleogel Á Hydrogel Á Hydrogel-in-oleogel bigel Á Oleogel-in-hydrogel bigel Á Moxifloxacin HCl Á Antimicrobial activity J Surfact Deterg (2018) 21: 17-29.

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Novel Fish Oil-based Bigel System for Controlled Drug Delivery and its Influence on Immunomodulatory Activity of Imiquimod Against Skin Cancer

Abstract: Imiquimod administration through a bigel vehicle along with fish oil could be beneficial for controlling imiquimod-induced inflammatory side effects and in the treatment of skin cancer.

Cited by 54 publications

References 37 publications

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Development of Bigels Based on Stearic Acid–Rice Bran Oil Oleogels and Tamarind Gum Hydrogels for Controlled Delivery Applications

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