Novel fatty acid-based pH-responsive nanostructured lipid carriers for enhancing antibacterial delivery

Osman, Nawras; Omolo, Calvin A.; Gannimani, Ramesh; Waddad, Ayman Y.; Rambharose, Sanjeev; Mocktar, Chunderika; Singh, Sima; Parboosing, Raveen

doi:10.1016/j.jddst.2019.101125

Cited by 20 publications

(10 citation statements)

References 51 publications

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“…( 2015 ) that showed marked inhibition of biofilm formation, swarming motility, and the hemolytic activity of P. aeruginosa by cinnamon bark oil. The enhanced anti-microbial activity in NLC-cinnamon oil gel may also contribute to nanoparticles with large surface area and the lipophilic nature of the NLCs which enable better bacterial cell penetration and uptake (Osman et al., 2019 ). Both NLC-cinnamon colloid and NLC-cinnamon gel showed statistically significant MIC again P. aeruginosa compared to the cinnamon oil group (post hoc Bonferroni’s test, p < .05).…”

Section: Resultsmentioning

confidence: 99%

Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection

2021

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Burn wound is usually associated by antibiotic-resistant Pseudomonas aeruginosa infection that worsens and complicates its management. An effective approach is to use natural antibiotics such as cinnamon oil as a powerful alternative. This study aims to investigate topical nanostructured lipid carrier (NLC) gel loaded cinnamon oil for Pseudomonas aeruginosa wound infection. A 2 4 full factorial design was performed to optimize the formulation with particle size 108.48 ± 6.35 nm, zeta potential −37.36 ± 4.01 mV, and EE% 95.39 ± 0.82%. FTIR analysis revealed no excipient interaction. Poloxamer 407 in a concentration 20% w/w NLC gel was prepared for topical application. Drug release exhibited an initial burst release in the first five hours, followed by a slow, sustained release of up to five days. NLC-cinnamon gel has a significant ability to control the drug release with the lowest minimum inhibitory concentration again P. aeruginosa compared to other formulations ( p < .05). In vivo study also showed NLC-cinnamon gel effectively healed the infected burned wound after a six-day treatment course with better antibacterial efficacy in burned animal models. Histological examination ensured the tolerability of NLC-cinnamon gel. The results suggest that nanoparticle-based cinnamon oil gel is a promising natural product against antibiotic-resistant strains of P. aeruginosa in wound infection.

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Section: Resultsmentioning

confidence: 99%

Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection

2021

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“…The obtained results demonstrate the pH-responsiveness feature of oleic acid-loaded contact lenses. Prior studies have reported the use of fatty acids for the synthesis of pH-responsive nanostructured lipid carriers [ 52 , 53 , 54 ]. Chen et al [ 54 ] reported using pH-responsive solid lipid nanoparticles based on sodium laurate and doxorubicin to improve the efficacy of multidrug resistance cancer chemotherapy.…”

Section: Resultsmentioning

confidence: 99%

Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses

Torres-Luna

Domszy

et al. 2021

Pharmaceutics

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This paper explores the use of fatty acids in silicone hydrogel contact lenses for extending the release duration of cationic drugs. Drug release kinetics was dependent on the carbon chain length of the fatty acid loaded in the lens, with 12-, 14- and 18-carbon chain length fatty acids increasing the uptake and the release duration of ketotifen fumarate (KTF) and tetracaine hydrochloride (THCL). Drug release kinetics from oleic acid-loaded lenses was evaluated in phosphate buffer saline (PBS) at different ionic strengths (I = 167, 500, 1665 mM); the release duration of KTF and THCL was decreased with increasing ionic strength of the release medium. Furthermore, the release of KTF and THCL in deionized water did not show a burst and was significantly slower compared to that in PBS. The release kinetics of KTF and THCL was significantly faster when the pH of the release medium was decreased from 7.4 towards 5.5 because of the decrease in the relative amounts of oleate anions in the lens mostly populated at the polymer–pore interfaces. The use of boundary charges at the polymer–pore interfaces of a contact lens to enhance drug partition and extend its release is further confirmed by loading cationic phytosphingosine in contact lenses to attract an anionic drug.

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“…Based on various methods of formulation, several pH‐responsive nanosystems were formulated and reported. These include the formulation of pH‐responsive vancomycin encapsulated nanosystems, such as solid lipid nanoparticles (SLNs) formulated using N ‐(2‐morpholinoethyl) oleamide (Mhule et al, 2018); nanostructured lipid carriers composed of two stearyl tails conjugated to bis‐β‐alanine head and oleic acid‐derived liquid lipid with two tails of oleic acid attached to a primary amine head (Osman et al, 2019); and chitosan nanoparticles composed of oleic acid coupled with 2,2‐dimethyl‐5,5 bis(hydroxymethyl)‐1,3‐dioxane and chitosan (Kalhapure, Jadhav, et al, 2017). All of the above formulations were tested for antibacterial efficacy against MRSA infections.…”

Section: Intrinsic Stimuli‐responsive Nanocarriers For Antibacterial mentioning

confidence: 99%

Intrinsic stimuli‐responsive nanocarriers for smart drug delivery of antibacterial agents—An in‐depth review of the last two decades

Devnarain

Osman

Fasiku

et al. 2020

WIREs Nanomed Nanobiotechnol

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Antibiotic resistance due to suboptimal targeting and inconsistent antibiotic release at bacterial infection sites has driven the formulation of stimuli‐responsive nanocarriers for antibacterial therapy. Unlike conventional nanocarriers, stimuli‐responsive nanocarriers have the ability to specifically enhance targeting and drug release profiles. There has been a significant escalation in the design and development of novel nanomaterials worldwide; in particular, intrinsic stimuli‐responsive antibiotic nanocarriers, due to their enhanced activity, improved targeted delivery, and superior potential for bacterial penetration and eradication. Herein, we provide an extensive and critical review of pH‐, enzyme‐, redox‐, and ionic microenvironment‐responsive nanocarriers that have been reported in literature to date, with an emphasis on the mechanisms of drug release, the nanomaterials used, the nanosystems constructed and the antibacterial efficacy of the nanocarriers. The review also highlights further avenues of research for optimizing their potential and commercialization. This review confirms the potential of intrinsic stimuli‐responsive nanocarriers for enhanced drug delivery and antibacterial killing. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Novel fatty acid-based pH-responsive nanostructured lipid carriers for enhancing antibacterial delivery

Cited by 20 publications

References 51 publications

Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection

Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection

Effect of Carbon Chain Length, Ionic Strength, and pH on the In Vitro Release Kinetics of Cationic Drugs from Fatty-Acid-Loaded Contact Lenses

Intrinsic stimuli‐responsive nanocarriers for smart drug delivery of antibacterial agents—An in‐depth review of the last two decades

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