Novel extracellular matrix architecture on excitatory neurons revealed by HaloTag-HAPLN1
Igal Sterin,
Ava Niazi,
Jennifer Kim
et al.
Abstract:The brain's extracellular matrix (ECM) regulates neuronal plasticity and animal behavior. ECM staining shows an aggregated pattern in a net-like structure around a subset of neurons and diffuse staining in the interstitial matrix. However, understanding the structural features of ECM deposition across various neuronal types and subcellular compartments remains limited. To visualize the organization pattern and assembly process of the hyaluronan-scaffolded ECM in the brain, we fused a HaloTag to HAPLN1, which l… Show more
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