Ann Rearden, Rosemary Hurford, Nhan Luu, Emily Kieu, Melissa Sandoval, Georgina Perez-Liz, Luis Del Valle, Henry Powell, T. Dianne Langford
Abstract:Particularly interesting cysteine histidine-rich (PINCH) protein functions as a shuttling protein in Schwann cells after peripheral nerve damage, during repair and remodeling, and in maintaining neuronal polarity. However, the presence of PINCH in the human CNS during disease has not been addressed. Because HIV-associated damage to cells of the CNS involves dysregulation of neuronal signaling and white matter damage, we hypothesized that PINCH may play a role in neuropathological processes during the course of…
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