Novel experimental approaches in the study of the immunopathology in inflammatory bowel disease

Reimann, Jörg; Rudolphi, Angelika; Claësson, Mogens H.

doi:10.1007/bf00198241

Cited by 22 publications

(14 citation statements)

References 68 publications

(55 reference statements)

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“…During the recent years, a variety of animal models have been generated to study the cellular and humoral components in the pathogenesis of colitis (7,8). In IL-10-deficient mice, who develop colitis spontaneously, it has been shown that B-cells are not necessary for disease development (9).…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

Immunoglobulin Leakiness in scid Mice with CD4+ T-Cell-Induced Chronic Colitis

Brimnes

Reimann

Claësson

2000

Clinical Immunology

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Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

Immunoglobulin Leakiness in scid Mice with CD4+ T-Cell-Induced Chronic Colitis

Brimnes

Reimann

Claësson

2000

Clinical Immunology

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“…A chronic intestinal inflammation with a resemblance to human IBD can be induced in immunodeficient hosts, such as severe combined immunodeficient (SCID) or recombination activating gene (RAG) mice, by the adoptive transfer of purified CD4+ T cells from immunocompetent syngenic donors [7][8][9]. The histopathology of IBD in CD4+ Tcell-transplanted SCID mice has previously been reviewed in detail [8,10] and will not be described further.…”

mentioning

confidence: 99%

Cells and Cytokines in the Pathogenesis of Inflammatory Bowel Disease: New Insights from Mouse T Cell Transfer Models

Bregenholt

2000

Exp Clin Immunogenet

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Recently, a number of experimental models of human inflammatory bowel disease (IBD) of immunological basis have been developed. These have proven useful tools in the study of IBD, allowing a more detailed dissection of the pathogenesis of the disease. Studies from these models have revealed new, important knowledge about environmental factors, cell subset, cytokines and effector molecules in the pathogenesis of IBD. This review focuses on recent advances in the understanding of the development of IBD obtained from adoptive CD4+ T cell transfer models of the disease.

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“…Because of the great number of IBD animal models different types of classification have been proposed [3,9,10]. First, the term 'IBD animal model' must be defined: An IBD animal model is characterized by chronic or relapsing inflammation of the GI tract with features resembling human IBD.…”

Section: Classification Of Ibd Animal Modelsmentioning

confidence: 99%

“…microbial; T-cell/MHC-related or spontaneous models, and mutant mice. At the same time Reimann et al [9] suggested making only 3 groups: genetic models (spontaneous, knock-out, and transgenic); adoptive transfer models, and models induced by exogenous agents. Most recently, Strober et al [3] proposed a new classification into only 2 groups where 1 group has a defect within the effector mechanism of the mucosal response (e.g.…”

Section: Classification Of Ibd Animal Modelsmentioning

confidence: 99%

Animal Models of Inflammatory Bowel Disease: An Overview

et al. 2002

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Inflammatory bowel disease (IBD) research has been performed in human in vitro studies and in in vivo studies using appropriate animal models. Such animal models allow both the examination of inflammatory processes (both early and late events) as well as the evaluation of new therapeutic modalities. Since the first description of the immune complex colitis in rabbits in 1961, overall 63 models have been described, most of which within the last decade. These IBD animal models can be divided into 5 different categories: (1) antigen-induced colitis and colitis induced by microbials; (2) other inducible forms of colitis (chemical, immunological, and physical); (3) genetic colitis models (transgenic and knock-out models); (4) adoptive transfer models, and (5) spontaneous colitis models. In spite of the high overall number of models, none of them is the ‘perfect’ model and therefore numerous aspects need to be considered when choosing one model for a particular study. Importantly, most clinical aspects (e.g. extraintestinal manifestations or fistula) have recently been described in one or the other model allowing further studies with relevance for almost all aspects of IBD. So far, IBD animal models have taught us important lessons, e.g. the requirement of T-helper cells in most models, the need of a particular genetic background, and the role of the flora in the initiation of IBD. It is expected that our understanding of IBD will further increase in a number of additional areas using animal models, e.g. exploring the role of the innate immune system in IBD.

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Novel experimental approaches in the study of the immunopathology in inflammatory bowel disease

Cited by 22 publications

References 68 publications

Immunoglobulin Leakiness in scid Mice with CD4+ T-Cell-Induced Chronic Colitis

Immunoglobulin Leakiness in scid Mice with CD4+ T-Cell-Induced Chronic Colitis

Cells and Cytokines in the Pathogenesis of Inflammatory Bowel Disease: New Insights from Mouse T Cell Transfer Models

Animal Models of Inflammatory Bowel Disease: An Overview

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