Novel evidence for enhanced stem cell trafficking in antipsychotic-naïve subjects during their first psychotic episode

Kucharska-Mazur, Jolanta; Tarnowski, Maciej; Dołęgowska, Barbara; Budkowska, Marta; Pędziwiatr, Daniel; Jabłoński, Marcin; Pełka-Wysiecka, Justyna; Kazimierczak, Arkadiusz; Ratajczak, Mariusz Z.; Samochowiec, Jerzy

doi:10.1016/j.jpsychires.2013.10.016

Cited by 35 publications

(44 citation statements)

References 53 publications

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“…These observations support the concept that VSELs are a mobile population of stem cells highly responsible for responding to stress situations and thus are most likely to be involved in repair mechanisms that require the contribution of stem cells. In further support of this concept, we observed that VSELs respond by chemotaxis to several factors that are released in damaged tissues, such as stromal derived factor-1 (SDF-1), hepatocyte growth factor (HGF), and leukemia inhibitory factor (LIF), as well as to phosphosphingolipids such as sphingosine-1-phosphate (S1P) and ceramic-1-phosphate (C1P) [62][63][64][92][93][94].…”

Section: Mobilization Of Vsels Into Pb In Response To Stress and Tissmentioning

confidence: 79%

Very small embryonic-like stem cells as a novel developmental concept and the hierarchy of the stem cell compartment

Ratajczak

Marycz

Poniewierska-Baran

et al. 2014

Advances in Medical Sciences

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Section: Mobilization Of Vsels Into Pb In Response To Stress and Tissmentioning

confidence: 79%

Very small embryonic-like stem cells as a novel developmental concept and the hierarchy of the stem cell compartment

Ratajczak

Marycz

Poniewierska-Baran

et al. 2014

Advances in Medical Sciences

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“…Applied treatment did not result in a reduction in the number of these stem cells. Established deviations can be potentially treated as an indicator of a disturbance within the development process of the brain, which remains in line with Weinberger’s theory of schizophrenia as a neurodevelopmental disorder [22]. …”

Section: Discussionmentioning

confidence: 94%

“…They did not, however, demonstrate changes in the concentrations of the other investigated factors. The results may also be used in differentiating between psychoses and anxiety disorders [22]. …”

Section: Discussionmentioning

confidence: 99%

“…Kucharska et al investigated the relationship between the first episode of psychosis and HSC and VSEL levels. They showed that in a group of people experiencing their first psychotic episode in comparison with the control group, the VSEL level is significantly higher [22]. The use of psychiatric drugs has an effect on the process of neurogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Mobilization of Peripheral Blood Stem Cells and Changes in the Concentration of Plasma Factors Influencing their Movement in Patients with Panic Disorder

Jabłoński

Mazur

Tarnowski

et al. 2016

Stem Cell Rev and Rep

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In this paper we examined whether stem cells and factors responsible for their movement may serve as new biological markers of anxiety disorders. The study was carried out on a group of 30 patients diagnosed with panic disorder (examined before and after treatment), compared to 30 healthy individuals forming the control group. We examined the number of circulating HSCs (hematopoetic stem cells) (Lin−/CD45 +/CD34 +) and HSCs (Lin−/CD45 +/AC133 +), the number of circulating VSELs (very small embryonic-like stem cells) (Lin−/CD45−/CD34 +) and VSELs (Lin−/CD45−/AC133 +), as well as the concentration of complement components: C3a, C5a and C5b-9, SDF-1 (stromal derived factor) and S1P (sphingosine-1-phosphate). Significantly lower levels of HSCs (Lin−/CD45 +/AC133 +) have been demonstrated in the patient group compared to the control group both before and after treatment. The level of VSELs (Lin−/CD45−/CD133 +) was significantly lower in the patient group before treatment as compared to the patient group after treatment.The levels of factors responsible for stem cell movement were significantly lower in the patient group compared to the control group before and after treatment. It was concluded that the study of stem cells and factors associated with their movement can be useful in the diagnostics of panic disorder, as well as differentiating between psychotic and anxiety disorders.

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“…Most patients were recruited in local psychiatric hospitals providing long-term care to the most severe cases of mental disorders [12,13].…”

Section: Patientsmentioning

confidence: 99%

Functional polymorphism of matrix metalloproteinase-9 (MMP9) gene is not associated with schizophrenia and with its deficit subtype

Bieńkowski

Samochowiec

Pełka-Wysiecka

et al. 2015

Pharmacological Reports

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Novel evidence for enhanced stem cell trafficking in antipsychotic-naïve subjects during their first psychotic episode

Cited by 35 publications

References 53 publications

Very small embryonic-like stem cells as a novel developmental concept and the hierarchy of the stem cell compartment

Very small embryonic-like stem cells as a novel developmental concept and the hierarchy of the stem cell compartment

Mobilization of Peripheral Blood Stem Cells and Changes in the Concentration of Plasma Factors Influencing their Movement in Patients with Panic Disorder

Functional polymorphism of matrix metalloproteinase-9 (MMP9) gene is not associated with schizophrenia and with its deficit subtype

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