Novel Etiological Agent: Molecular Evidence for Trematode-Induced Anterior Uveitis in Children

Rathinam, Sivakumar R.; Arya, Lalan Kumar; Kim, Usha; Lalitha, Prajna; Tandon, Veena

doi:10.1001/archophthalmol.2012.729

Cited by 27 publications

(15 citation statements)

References 5 publications

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“…On the basis of histopathologic work-up, researchers from our hospital previously reported possible trematode infection in a large group of children with ocular inflammation ( 17 , 18 ). We later reported molecular evidence that established the trematode Procerovum varium as the source of the ocular granuloma in a single patient from the same region as that of the children in the previous study ( 19 ).…”

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confidence: 77%

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Trematode FlukeProcerovumvariumas Cause of Ocular Inflammation in Children, South India

Arya¹,

Rathinam²,

Lalitha³

et al. 2016

Emerg. Infect. Dis.

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confidence: 77%

“…Our previous study involving a single patient with ocular granuloma pointed to infection by the trematode P. varium ( 19 ). During March 2010–February 2013, ocular complications were being detected in children in South India in whom ocular granulomas developed after they were exposed to snail-infested water in ponds or rivers.…”

mentioning

confidence: 99%

Trematode FlukeProcerovumvariumas Cause of Ocular Inflammation in Children, South India

Arya¹,

Rathinam²,

Lalitha³

et al. 2016

Emerg. Infect. Dis.

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“…Although the lung is the organ most frequently involved (approximately 90% of cases), other organs such as the skin, lymph nodes and eyes are also common targets 9. Nodular infiltrations associated with sarcoidosis may affect any ocular tissue.…”

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confidence: 99%

Diffuse Berlin nodules: unusual presentation of ocular sarcoidosis

Kassa¹,

Elner

Moroi

et al. 2013

Br J Ophthalmol

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“…Several attempts have been made to identify the aetiology of such lesions. A molecular evidence of digenetic trematode has been reported as a cause of such peculiar inflammation in recent studies (Rathinam et al 2012;Arya et al 2016;Amin et al 2017;Amin et al 2019).…”

Section: Introductionmentioning

confidence: 96%

Anterior chamber granuloma: conservative treatment versus surgical intervention

Sadek

Ahmed

Kamal

et al. 2020

Acta Ophthalmologica

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Purpose A distinct pattern of granulomatous anterior uveitis, with white anterior chamber (AC) granuloma, has been reported in certain endemic areas. The aim of this work was to compare the outcome of conservative treatment to surgical intervention for the treatment of large AC granulomas presenting with moderate–severe anterior uveitis. The secondary outcome is ultrasound biomicroscopy (UBM) characterization of AC granulomas. Methods This is a prospective randomized interventional study including 41 eyes of 39 patients with active AC granuloma ≥3 mm (flare & cells ≥ +2). Patients were randomly assigned to either conservative treatment in the form of topical prednisolone and cycloplegic drops with orbital floor (transseptal) injection of Triamcinolone acetonide (20 eyes) or surgery in the form of granuloma excision and AC wash (21 eyes). As a perioperative care, topical steroids and cycloplegic drops were given few days before surgery and tapered gradually over 6 weeks. Patients were followed up at first day, 2 weeks, 1 and 3 months. Results Thirty‐seven patients were males, and 2 were females (13.0 ± 3.5 years). After 2 weeks, disappearance/healing of granuloma was achieved in 20 eyes in the surgical group versus 2 eyes in the conservative group (p < 0.0001). This effect was maintained throughout the follow‐up period, for the surgical group and reached up to 70%, for the medical group. At every follow‐up, BCVA was better in the surgical group, but this was only statistically significant at 1 and 3 months. The granuloma appeared as a homogenous hyperreflective lesion in examined eyes (16 eyes of 15 patients). Conclusion Surgical treatment of large granulomas leads to a more complete and rapid resolution of inflammation.

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Novel Etiological Agent: Molecular Evidence for Trematode-Induced Anterior Uveitis in Children

Cited by 27 publications

References 5 publications

Trematode FlukeProcerovumvariumas Cause of Ocular Inflammation in Children, South India

Trematode FlukeProcerovumvariumas Cause of Ocular Inflammation in Children, South India

Diffuse Berlin nodules: unusual presentation of ocular sarcoidosis

Anterior chamber granuloma: conservative treatment versus surgical intervention

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