Novel Estimates of Renal Function are Associated with Short-Term Left Ventricular Assist Device Outcomes

George, Timothy J.; Biedermann, Scott; DiMaio, J. Michael; Kabra, Nitin; Rawitscher, David; Afzal, Aasim

doi:10.1016/j.jss.2022.10.072

Cited by 1 publication

(1 citation statement)

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“…Kidney dysfunction [assessed generally using serum creatinine, derived estimated glomerular filtration rate (eGFR), or blood urea nitrogen (BUN)] is common prior to LVAD implantation and associated with adverse outcomes [19 ▪ ,20]. Various measures of preimplantation kidney function are used in most prognostic models developed to risk stratify persons prior to LVAD implantation [21].…”

Section: Kidney Health and Left Ventricular Assist Devices: Durable M...mentioning

confidence: 99%

Kidney health and function with left ventricular assist devices

Garcia

Walther

2023

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewMechanical circulatory support (MCS) is a group of evolving therapies used for indications ranging from temporary support during a cardiac procedure to permanent treatment of advanced heart failure. MCS is primarily used to support left ventricle function, in which case the devices are termed left ventricular assist devices (LVADs). Kidney dysfunction is common in patients requiring these devices, yet the impact of MCS itself on kidney health in many settings remains uncertain.Recent findingsKidney dysfunction can manifest in many different forms in patients requiring MCS. It can be because of preexisting systemic disorders, acute illness, procedural complications, device complications, and long-term LVAD support. After durable LVAD implantation, most persons have improvement in kidney function; however, individuals can have markedly different kidney outcomes, and novel phenotypes of kidney outcomes have been identified.SummaryMCS is a rapidly evolving field. Kidney health and function before, during, and after MCS is relevant to outcomes from an epidemiologic perspective, yet the pathophysiology underlying this is uncertain. Improved understanding of the relationship between MCS use and kidney health is important to improving patient outcomes.

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Section: Kidney Health and Left Ventricular Assist Devices: Durable M...mentioning

confidence: 99%